One of the most urgent needs worldwide is to vaccinate against SARS-CoV-2 as many people as possible. We evaluated humoral response to Comirnaty vaccine in Thalassemia Major patients (TM). We measured SARS-CoV-2-specific antibodies against Spike protein in 57 TM patients and 58 healthy blood donors (HBD). TM and HBD subjects revealed a homogeneous serological response to the Comirnaty (Mean±SD; TM=1917,21±1384,49; HBD=2039,81±1064,44; p=0,5884). No statistically significant differences were observed among two groups. Interestingly, we observed in 73.3% of asplenic patients Ab-S titres above 800 BAU, whereas only in 26% of non splenectomized patients showed Ab-S titres above 800 BAU). This differences were statistically significant p< 0.039. Further measurement on other Ab types was needed for better understanding humoral response to Comirnaty.

Humoral Immune response to Comirnaty ({BNT}162b2) {SARS}-Cov2 {mRNA} vaccine in Thalassemia Major patients / Anastasi, Emanuela; Marziali, Marco; Preziosi, Adele; Berardelli, Elena; Annunziata Losardo, Anna; Ribersani, Michela; Pugliese, Pellegrina; Farina, Antonella; Mancini, Patrizia; Angeloni, Antonio. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - (2022). [10.1016/j.micinf.2022.104976]

Humoral Immune response to Comirnaty ({BNT}162b2) {SARS}-Cov2 {mRNA} vaccine in Thalassemia Major patients

Emanuela Anastasi
Writing – Original Draft Preparation
;
Marco Marziali
Membro del Collaboration Group
;
Adele Preziosi
Data Curation
;
Elena Berardelli
Investigation
;
Antonella Farina
Writing – Original Draft Preparation
;
Patrizia Mancini
Membro del Collaboration Group
;
Antonio Angeloni
Supervision
2022

Abstract

One of the most urgent needs worldwide is to vaccinate against SARS-CoV-2 as many people as possible. We evaluated humoral response to Comirnaty vaccine in Thalassemia Major patients (TM). We measured SARS-CoV-2-specific antibodies against Spike protein in 57 TM patients and 58 healthy blood donors (HBD). TM and HBD subjects revealed a homogeneous serological response to the Comirnaty (Mean±SD; TM=1917,21±1384,49; HBD=2039,81±1064,44; p=0,5884). No statistically significant differences were observed among two groups. Interestingly, we observed in 73.3% of asplenic patients Ab-S titres above 800 BAU, whereas only in 26% of non splenectomized patients showed Ab-S titres above 800 BAU). This differences were statistically significant p< 0.039. Further measurement on other Ab types was needed for better understanding humoral response to Comirnaty.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1627870
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