The ongoing SARS-CoV-2 pandemic, which is dramatically spreading worldwide, is well known for its respiratory sequelae. Besides cases of Guillain-Barré Syndrome, encephalitis, hyposmia, the whole range of neurological complications due to SARSCoV-2 is still not well known. Herein, we report a new case of COVID-19, associated with mononeuropathy with reversible conduction block (CB). After SARS-CoV-2 infection, the patient developed acute weakness of left peroneal muscles. He underwent an endovenous immunoglobulin treatment, and symptoms improved. Two electroneurographic exam (before and after treatment), showed a reversible CB on left peroneal nerve. Dosage of serum antiganglioside antibodies showed anti-GM1 IgM positivity. The present case gives new informations about reversible CB neuropathy as an acute presentation of SARS-CoV-2. Besides, antiganglioside antibodies evaluation could be useful to understand etiology of the increasing number of neurological manifestations related to SARS-CoV-2.

Reversible conduction block of peroneal nerve associated with SARS‑CoV‑2 / Cioffi, E; Davide, Dilenola; Luigi, Iuliano; Alessandro, Polidoro; Carlo, Casali; Mariano, Serrao. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-3478. - (2021). [https://doi.org/10.1007/s10072-021-05655-8]

Reversible conduction block of peroneal nerve associated with SARS‑CoV‑2

CIOFFI E;Luigi Iuliano;Mariano Serrao
2021

Abstract

The ongoing SARS-CoV-2 pandemic, which is dramatically spreading worldwide, is well known for its respiratory sequelae. Besides cases of Guillain-Barré Syndrome, encephalitis, hyposmia, the whole range of neurological complications due to SARSCoV-2 is still not well known. Herein, we report a new case of COVID-19, associated with mononeuropathy with reversible conduction block (CB). After SARS-CoV-2 infection, the patient developed acute weakness of left peroneal muscles. He underwent an endovenous immunoglobulin treatment, and symptoms improved. Two electroneurographic exam (before and after treatment), showed a reversible CB on left peroneal nerve. Dosage of serum antiganglioside antibodies showed anti-GM1 IgM positivity. The present case gives new informations about reversible CB neuropathy as an acute presentation of SARS-CoV-2. Besides, antiganglioside antibodies evaluation could be useful to understand etiology of the increasing number of neurological manifestations related to SARS-CoV-2.
2021
Neuroimmunology; Peripheral neuropathy; CIDP; Antiganglioside antibodies; SARS-CoV-2; COVID-19
01 Pubblicazione su rivista::01a Articolo in rivista
Reversible conduction block of peroneal nerve associated with SARS‑CoV‑2 / Cioffi, E; Davide, Dilenola; Luigi, Iuliano; Alessandro, Polidoro; Carlo, Casali; Mariano, Serrao. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-3478. - (2021). [https://doi.org/10.1007/s10072-021-05655-8]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1619812
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