Metabolic Syndrome and Physical Inactivity May Be Shared Etiological Agents of Prostate Cancer and Coronary Heart Diseases

As metabolic syndrome (MetS) and a sedentary lifestyle have been associated with anincreased risk of developing both prostate cancer (PCa) and cardiovascular diseases (CVDs), the2 conditions may share a common etiology. We aimed at investigating the association between CVDsand PCa. A retrospective analysis was performed. Our dataset on patients undergone systematicprostate biopsy was searched for histopathologic and clinical data. The physical activity (PA) scale forthe elderly (PASE) was collected. Coronary heart diseases (CHDs) were recorded. Prognostic GradeGroup≥3 tumors were defined as high-grade (HG). The association between MetS, PA, CHDs andPCa was assessed using logistic regression analyses. Data on 955 patients were collected; 209 (22%)presented with MetS, 79 (8%) with CHDs. PCa was diagnosed in 395 (41.3%) men and 60%(n= 238)presented with an high-grade tumor. CHDs were more common among PCa-patients (9.4% vs. 7.5%;p= 0.302) but the difference was not statistically significant. No difference was observed between low-and high-grade subgroups (9.5% vs. 9.2%;p= 0.874). PASE independently predicted PCa diagnosis(OR: 0.287;p= 0.001) and HG-PCa (OR: 0.165;p= 0.001). MetS was an independent predictor ofHG-PCa only (OR: 1.50; 95% CI: 1.100–2.560;p= 0.023). CHDs were not associated with tumordiagnosis and aggressiveness