The discovery of gene driver mutations and the increase of next-generation sequencing techniques have radically changed the natural history of NSCLCs. Neuroendocrine lung cancers are a heterogeneous entity whose biology is little known. Sporadic actionable mutations are also reported in this subtype of neoplasms, especially in tumors derived from a transformation of adenocarcinomas. ROS-1 gene rearrangements are found in about 1-2% of lung neoplasms and are characterized by a high sensitivity to specific tyrosine kinase inhibitors (TKis). Here we report the case of a large cell neuroendocrine carcinoma precisely framed and treated thanks to a next-generation genomic approach.
Comprehensive genomic profiling in large cell neuroendocrine lung cancer: the times they are a-changin' / Filetti, M.; Piras, M.; Giusti, R.. - In: RECENTI PROGRESSI IN MEDICINA. - ISSN 0034-1193. - 112:1(2021), pp. E1-E4. [10.1701/3525.35130]
Comprehensive genomic profiling in large cell neuroendocrine lung cancer: the times they are a-changin'
Filetti M.
Primo
;Piras M.;
2021
Abstract
The discovery of gene driver mutations and the increase of next-generation sequencing techniques have radically changed the natural history of NSCLCs. Neuroendocrine lung cancers are a heterogeneous entity whose biology is little known. Sporadic actionable mutations are also reported in this subtype of neoplasms, especially in tumors derived from a transformation of adenocarcinomas. ROS-1 gene rearrangements are found in about 1-2% of lung neoplasms and are characterized by a high sensitivity to specific tyrosine kinase inhibitors (TKis). Here we report the case of a large cell neuroendocrine carcinoma precisely framed and treated thanks to a next-generation genomic approach.File | Dimensione | Formato | |
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