Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. This effect also correlated with the induction of pro-survival autophagy by curcumin and its inhibition by resveratrol. In conclusion, this study unveils new molecular mechanisms underlying the anti-cancer effects of resveratrol, curcumin and their combination, which can help to design new therapeutic strategies based on the use of these polyphenols.

New insights into curcumin-and resveratrol-mediated anti-cancer effects / Arena, A.; Romeo, M. A.; Benedetti, R.; Masuelli, L.; Bei, R.; Gilardini Montani, M. S.; Cirone, M.. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 14:11(2021), pp. 1-12. [10.3390/ph14111068]

New insights into curcumin-and resveratrol-mediated anti-cancer effects

Arena A.;Romeo M. A.;Benedetti R.;Masuelli L.;Gilardini Montani M. S.;Cirone M.
2021

Abstract

Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. This effect also correlated with the induction of pro-survival autophagy by curcumin and its inhibition by resveratrol. In conclusion, this study unveils new molecular mechanisms underlying the anti-cancer effects of resveratrol, curcumin and their combination, which can help to design new therapeutic strategies based on the use of these polyphenols.
2021
autophagy; curcumin; er stress; her-2/neu cancers; pi3k/akt/mtor; resveratrol
01 Pubblicazione su rivista::01a Articolo in rivista
New insights into curcumin-and resveratrol-mediated anti-cancer effects / Arena, A.; Romeo, M. A.; Benedetti, R.; Masuelli, L.; Bei, R.; Gilardini Montani, M. S.; Cirone, M.. - In: PHARMACEUTICALS. - ISSN 1424-8247. - 14:11(2021), pp. 1-12. [10.3390/ph14111068]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1587474
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