Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. The authors investigated the role of autophagy, oxidative stress, and endothelial dysfunction in 36 TAA patients and 23 control patients. Univariable and multivariable analyses were performed. TAA patients displayed higher oxidative stress and endothelial dysfunction then control patients. Autophagy in the TAA group was reduced. The association of oxidative stress and autophagy with aortic disease supports the role of these processes in TAA. The authors demonstrate a putative role of Nox2 and autophagy dysregulation in human TAA. These findings could pinpoint novel treatment targets to prevent or limit TAA progression.

Role of oxidative stress and autophagy in thoracic aortic aneurysms / Irace, Francesco G.; Cammisotto, Vittoria; Valenti, Valentina; Maurizio, Forte; Schirone, Leonardo; Bartimoccia, Simona; Alessandra, Iaccarino; Peruzzi, Mariangela; Schiavon, Sonia; Morelli, Andrea; Marullo, Antonino G. M.; Miraldi, Fabio; Nocella, Cristina; Ruggero De Paulis, ; Umberto, Benedetto; Greco, Ernesto; BIONDI ZOCCAI, Giuseppe; Sciarretta, Sebastiano; Carnevale, Roberto; Frati, Giacomo. - In: JACC. BASIC TO TRANSLATIONAL SCIENCE. - ISSN 2452-302X. - 6:9/10(2021), pp. 719-730. [10.1016/j.jacbts.2021.08.002]

Role of oxidative stress and autophagy in thoracic aortic aneurysms

Francesco G. Irace
Co-primo
;
Vittoria Cammisotto
Co-primo
;
Valentina Valenti;Leonardo Schirone;Simona Bartimoccia;Mariangela Peruzzi;Sonia Schiavon;Andrea Morelli;Antonino G. M. Marullo;Fabio Miraldi;Cristina Nocella;Ernesto Greco;Giuseppe Biondi-Zoccai;Sebastiano Sciarretta;Roberto Carnevale
Penultimo
;
Giacomo Frati
Ultimo
2021

Abstract

Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. The authors investigated the role of autophagy, oxidative stress, and endothelial dysfunction in 36 TAA patients and 23 control patients. Univariable and multivariable analyses were performed. TAA patients displayed higher oxidative stress and endothelial dysfunction then control patients. Autophagy in the TAA group was reduced. The association of oxidative stress and autophagy with aortic disease supports the role of these processes in TAA. The authors demonstrate a putative role of Nox2 and autophagy dysregulation in human TAA. These findings could pinpoint novel treatment targets to prevent or limit TAA progression.
2021
thoracic aortic aneurysm; autophagy; oxidative stress; Nox2
01 Pubblicazione su rivista::01a Articolo in rivista
Role of oxidative stress and autophagy in thoracic aortic aneurysms / Irace, Francesco G.; Cammisotto, Vittoria; Valenti, Valentina; Maurizio, Forte; Schirone, Leonardo; Bartimoccia, Simona; Alessandra, Iaccarino; Peruzzi, Mariangela; Schiavon, Sonia; Morelli, Andrea; Marullo, Antonino G. M.; Miraldi, Fabio; Nocella, Cristina; Ruggero De Paulis, ; Umberto, Benedetto; Greco, Ernesto; BIONDI ZOCCAI, Giuseppe; Sciarretta, Sebastiano; Carnevale, Roberto; Frati, Giacomo. - In: JACC. BASIC TO TRANSLATIONAL SCIENCE. - ISSN 2452-302X. - 6:9/10(2021), pp. 719-730. [10.1016/j.jacbts.2021.08.002]
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Note: https://doi.org/10.1016/j.jacbts.2021.08.002
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1571385
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