We report the case of a 65-year-old man with acute GFR decline to 37 mL/min and uncontrolled high blood pressure. He was suspected for renovascular hypertension and underwent a renal color Doppler ultrasound scan that detected a bilateral atherosclerotic renal artery stenosis. A digital selective angiography by percutaneous transluminal angioplasty and stenting (PTRAs) was successfully performed. Blood pressure rapidly normalized, GFR increased within a few days, and proteinuria disappeared thereafter. These clinical goals were accompanied by a significant increase of circulating renal stem cells (RSC) and a slight increase of resistive index (RI) in both kidneys. This single observation suggests the need for extensive studies aimed at evaluating the predictive power of RI and RSC in detecting post-ischemic renal repair mechanisms.
Ischemic nephropaty: the role of the renal artery stenosis re-vascularization on renal stem cells / Cianci, Rosario; Lai, Silvia; Ferri, Claudio; Mazzaferro, Sandro; Simeoni, Mariaadelina; Gigante, Antonietta; Perrotta, ADOLFO MARCO; Errigo, Federica; Cianci, Eleonora. - In: MEDICINA. - ISSN 1648-9144. - (2021), pp. 57, 944-59, 944. [10.3390/medicina57090944]
Ischemic nephropaty: the role of the renal artery stenosis re-vascularization on renal stem cells
cianci rosario;lai silvia;Ferri ClaudioMembro del Collaboration Group
;Mazzaferro Sandro;Gigante AntoniettaSupervision
;Adolfo marco Perrotta
;Errigo Federica;
2021
Abstract
We report the case of a 65-year-old man with acute GFR decline to 37 mL/min and uncontrolled high blood pressure. He was suspected for renovascular hypertension and underwent a renal color Doppler ultrasound scan that detected a bilateral atherosclerotic renal artery stenosis. A digital selective angiography by percutaneous transluminal angioplasty and stenting (PTRAs) was successfully performed. Blood pressure rapidly normalized, GFR increased within a few days, and proteinuria disappeared thereafter. These clinical goals were accompanied by a significant increase of circulating renal stem cells (RSC) and a slight increase of resistive index (RI) in both kidneys. This single observation suggests the need for extensive studies aimed at evaluating the predictive power of RI and RSC in detecting post-ischemic renal repair mechanisms.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
