We optimized a high density and low polydispersion phase change microdroplets (MDs) system consisting of a decafluoropentane core (DFP) [1] and a dioctadecylammonium bromide shell (DDAB). We propose an effective and non-toxic vector able to transfect nucleic acids into the cells due to DDAB peculiarities as well as capable to release the loaded drug, [2]. The development of this system is aimed at application in non-viral gene therapy and can synergistically carry out a genic and chemotherapy activity on tumor cells (Sk-Mel 28) to counteract cellular drug resistance. [3]
Ultrasound responsive microdroplets as a synergistic gene-drug delivery agent on human melanoma cells / Ditri, Angela; Piermarini, Martina; Palmieri, Damiano; Tortorella, Elisabetta; Porchetta, Alessandro; Domenici, Fabio; Paradossi, Gaio. - (2021). (Intervento presentato al convegno 5th International Caparica Conference on Ultrasonic-based applications from analysis to synthesis tenutosi a Caparica; Portugal).
Ultrasound responsive microdroplets as a synergistic gene-drug delivery agent on human melanoma cells
Elisabetta Tortorella;
2021
Abstract
We optimized a high density and low polydispersion phase change microdroplets (MDs) system consisting of a decafluoropentane core (DFP) [1] and a dioctadecylammonium bromide shell (DDAB). We propose an effective and non-toxic vector able to transfect nucleic acids into the cells due to DDAB peculiarities as well as capable to release the loaded drug, [2]. The development of this system is aimed at application in non-viral gene therapy and can synergistically carry out a genic and chemotherapy activity on tumor cells (Sk-Mel 28) to counteract cellular drug resistance. [3]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
