Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer's disease to cancer.

Viral Infection and Autophagy Dysregulation. The Case of HHV-6, EBV and KSHV / Romeo, M. A.; Santarelli, R.; Gilardini Montani, M. S.; Gonnella, R.; Benedetti, R.; Faggioni, A.; Cirone, M.. - In: CELLS. - ISSN 2073-4409. - 9:12(2020), pp. 1-8.

Viral Infection and Autophagy Dysregulation. The Case of HHV-6, EBV and KSHV

Romeo M. A.;Santarelli R.;Gilardini Montani M. S.;Gonnella R.;Benedetti R.;Faggioni A.;Cirone M.
2020

Abstract

Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer's disease to cancer.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1546732
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