Recently, there is a growing demand in sustainable phytopathogens control research. Nanotechnology provides several tools such as new pesticides formulations, antibacterial nanomaterials and smart delivery systems. Metal nano-oxides and different biopolymers have been exploited in order to develop nanopesticides which can offer a targeted solution minimizing side effects on environment and human health. Thiswork proposed a nanotechnological approach to obtain a newformulation of systemic fungicide fosetyl-Al employing ultrasonication assisted production of water dispersible nanocrystals. Moreover, chitosan was applicated as a coating agent aiming a synergistic antimicrobial effect between biopolymer and fungicide. Fosetyl-Al nanocrystals have been characterized by morphological and physical-chemical analysis. Nanotoxicological investigationwas carried out on human keratinocytes cells through cells viability test and ultrastructural analysis. In vitro planktonic growth, biofilm production and agar dilution assays have been conducted on twoXylella fastidiosa subspecies. Fosetyl-Al nanocrystals resulted very stable over time and less toxic respect to conventional formulation. Finally, chitosan-based fosetyl-Al nanocrystals showed an interesting antibacterial activity against Xylella fastidiosa subsp. pauca and Xylella fastidiosa subsp. fastidiosa

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa / Baldassarre, Francesca; Tatulli, Giuseppe; Vergaro, Viviana; Mariano, Stefania; Scala, Valeria; Nobile, Concetta; Pucci, Nicoletta; Dini, Luciana; Loreti, Stefania; Ciccarella, Giuseppe. - In: NANOMATERIALS. - ISSN 2079-4991. - 10:6(2020), pp. 1-20. [10.3390/nano10061174]

Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa

Luciana Dini;
2020

Abstract

Recently, there is a growing demand in sustainable phytopathogens control research. Nanotechnology provides several tools such as new pesticides formulations, antibacterial nanomaterials and smart delivery systems. Metal nano-oxides and different biopolymers have been exploited in order to develop nanopesticides which can offer a targeted solution minimizing side effects on environment and human health. Thiswork proposed a nanotechnological approach to obtain a newformulation of systemic fungicide fosetyl-Al employing ultrasonication assisted production of water dispersible nanocrystals. Moreover, chitosan was applicated as a coating agent aiming a synergistic antimicrobial effect between biopolymer and fungicide. Fosetyl-Al nanocrystals have been characterized by morphological and physical-chemical analysis. Nanotoxicological investigationwas carried out on human keratinocytes cells through cells viability test and ultrastructural analysis. In vitro planktonic growth, biofilm production and agar dilution assays have been conducted on twoXylella fastidiosa subspecies. Fosetyl-Al nanocrystals resulted very stable over time and less toxic respect to conventional formulation. Finally, chitosan-based fosetyl-Al nanocrystals showed an interesting antibacterial activity against Xylella fastidiosa subsp. pauca and Xylella fastidiosa subsp. fastidiosa
2020
ultrasonics; fosetyl-Al; chitosan; nanopesticides; Xylella fastidiosa; nanotoxicity
01 Pubblicazione su rivista::01a Articolo in rivista
Sonication-Assisted Production of Fosetyl-Al Nanocrystals: Investigation of Human Toxicity and In Vitro Antibacterial Efficacy against Xylella fastidiosa / Baldassarre, Francesca; Tatulli, Giuseppe; Vergaro, Viviana; Mariano, Stefania; Scala, Valeria; Nobile, Concetta; Pucci, Nicoletta; Dini, Luciana; Loreti, Stefania; Ciccarella, Giuseppe. - In: NANOMATERIALS. - ISSN 2079-4991. - 10:6(2020), pp. 1-20. [10.3390/nano10061174]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1542761
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