Pulmonary arterial hypertension (PAH) is a rare, progressive disease with a poor prognosis. The pathophysiologic model is mainly characterized by an afterload mismatch in which an increased right ventricle afterload, driven by increased pulmonary vascular resistance (PVR), leads to right heart failure. International guidelines recommend optimization of treatment based on regular risk assessments to achieve or maintain a low-risk status. Current risk scores are based on a multi-modality approach, including demographic, clinical, functional, exercise, laboratory, and hemodynamic parameters, which lack significant echocardiographic parameters. The originality of echocardiography relies on the opportunity to assess in a non-invasive way a physiologically meaningful combination of easy to measure variables tightly related to right ventricle adaptation/maladaptation to increased afterload, the main determinant of a patient's prognosis. Echo-derived morphological and functional parameters have been investigated in PAH, proving to have prognostic relevance. Different therapeutic strategies proved to have different effects in reducing PVR. An upfront combination of drugs, including a parenteral prostacyclin, has shown to be associated with right heart reverse remodeling in a greater proportion of patients than other treatment strategies as a function of PVR reduction. Adding echocardiographic data to current risk scores would allow better identification of right ventricle (RV) adaptation in PAH patients' follow-up. This additional information would allow better stratification of the patient, leading to optimized and personalized therapeutic management.

The growing role of echocardiography in pulmonary arterial hypertension risk stratification. the missing piece / Miotti, C; Papa, S; Manzi, G; Scoccia, G; Luongo, F; Toto, F; Malerba, C; Cedrone, N; Sciomer, S; Ciciarello, F; Fedele, F; Vizza, Cd; Badagliacca, R. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:4(2021), p. 9. [10.3390/jcm10040619]

The growing role of echocardiography in pulmonary arterial hypertension risk stratification. the missing piece

Miotti, C;Papa, S;Manzi, G;Scoccia, G;Luongo, F;Toto, F;Malerba, C;Sciomer, S;Ciciarello, F;Fedele, F;Vizza, CD;Badagliacca, R
2021

Abstract

Pulmonary arterial hypertension (PAH) is a rare, progressive disease with a poor prognosis. The pathophysiologic model is mainly characterized by an afterload mismatch in which an increased right ventricle afterload, driven by increased pulmonary vascular resistance (PVR), leads to right heart failure. International guidelines recommend optimization of treatment based on regular risk assessments to achieve or maintain a low-risk status. Current risk scores are based on a multi-modality approach, including demographic, clinical, functional, exercise, laboratory, and hemodynamic parameters, which lack significant echocardiographic parameters. The originality of echocardiography relies on the opportunity to assess in a non-invasive way a physiologically meaningful combination of easy to measure variables tightly related to right ventricle adaptation/maladaptation to increased afterload, the main determinant of a patient's prognosis. Echo-derived morphological and functional parameters have been investigated in PAH, proving to have prognostic relevance. Different therapeutic strategies proved to have different effects in reducing PVR. An upfront combination of drugs, including a parenteral prostacyclin, has shown to be associated with right heart reverse remodeling in a greater proportion of patients than other treatment strategies as a function of PVR reduction. Adding echocardiographic data to current risk scores would allow better identification of right ventricle (RV) adaptation in PAH patients' follow-up. This additional information would allow better stratification of the patient, leading to optimized and personalized therapeutic management.
2021
pulmonary arterial hypertension; risk score; echocardiography
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The growing role of echocardiography in pulmonary arterial hypertension risk stratification. the missing piece / Miotti, C; Papa, S; Manzi, G; Scoccia, G; Luongo, F; Toto, F; Malerba, C; Cedrone, N; Sciomer, S; Ciciarello, F; Fedele, F; Vizza, Cd; Badagliacca, R. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:4(2021), p. 9. [10.3390/jcm10040619]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1524312
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