An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering / Farina, A.; Labriola, R.; Ialongo, C.; Suppa, M.; Lucarelli, M.; Anastasi, E.; Angeloni, A.. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - 23:4-5(2021). [10.1016/j.micinf.2021.104808]
Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering
Farina A.Primo
Investigation
;Labriola R.Secondo
Resources
;Ialongo C.Data Curation
;Suppa M.Resources
;Lucarelli M.Membro del Collaboration Group
;Anastasi E.
Penultimo
Writing – Review & Editing
;Angeloni A.Ultimo
Project Administration
2021
Abstract
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.| File | Dimensione | Formato | |
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