An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.

Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering / Farina, A.; Labriola, R.; Ialongo, C.; Suppa, M.; Lucarelli, M.; Anastasi, E.; Angeloni, A.. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - 23:4-5(2021). [10.1016/j.micinf.2021.104808]

Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering

Farina A.
Primo
Investigation
;
Labriola R.
Secondo
Resources
;
Ialongo C.
Data Curation
;
Suppa M.
Resources
;
Lucarelli M.
Membro del Collaboration Group
;
Anastasi E.
Penultimo
Writing – Review & Editing
;
Angeloni A.
Ultimo
Project Administration
2021

Abstract

An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
File allegati a questo prodotto
File Dimensione Formato  
Farina_Transient-plasma_2021.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 749.87 kB
Formato Adobe PDF
749.87 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1522731
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
social impact