Objectives: To describe patients according to the maximum degree of respiratory support received and report their inpatient mortality due to coronavirus disease 2019.Design: Analysis of patients in the Coracle registry from February 22, 2020, to April 1, 2020.Setting: Hospitals in the Piedmont, Lombardy, Tuscany, and Lazio regions of Italy.Patients: Nine-hundred forty-eight patients hospitalized for coronavirus disease 2019.Interventions: None.Measurements and Main Results: Among 948 patients, 122 (12.87%) received invasive ventilation, 637 (67.19%) received supplemental oxygen only, and 189 (19.94%) received no respiratory support. The median (quartile 1-quartile 3) age was 65 years (54-76.59 yr), and there was evidence of differential respiratory treatment by decade of life (p = 0.0046); patients greater than 80 years old were generally not intubated. There were 606 men (63.9%) in this study, and they were more likely to receive respiratory support than women (p < 0.0001). The rate of in-hospital death for invasive ventilation recipients was 22.95%, 12.87% for supplemental oxygen recipients, and 7.41% for those who received neither (p = 0.0004). A sensitivity analysis of the 770 patients less than 80 years old revealed a lower, but similar mortality trend (18.02%, 8.10%, 5.23%; p = 0.0008) among the 14.42%, 65.71%, and 19.87% of patients treated with mechanical ventilation, supplemental oxygen only, or neither. Overall, invasive ventilation recipients who died were significantly older than those who survived (median age: 68.5 yr [60-81.36 yr] vs 62.5 yr [55.52-71 yr]; p = 0.0145).Conclusions: Among patients hospitalized for coronavirus disease 2019, 13% received mechanical ventilation, which was associated with a mortality rate of 23%.

Inpatient mortality according to level of respiratory support received for severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) infection. a prospective multicenter study / Palazzuoli, Alberto; Ruberto, Franco; De Ferrari, Gaetano M; Forleo, Giovanni; Secco, Gioel G; Ruocco, Gaetano M; D'Ascenzo, Fabrizio; Mojoli, Francesco; Monticone, Silvia; Paggi, Anita; Vicenzi, Marco; Corcione, Silvia; Palazzo, Anna G; Landolina, Maurizio; Taravelli, Erika; Tavazzi, Guido; Blasi, Francesco; Mancone, Massimo; Birtolo, Lucia I; Alessandri, Francesco; Infusino, Fabio; Pugliese, Francesco; Fedele, Francesco; De Rosa, Francesco Giuseppe; Emmett, Michael; Schussler, Jeffrey M; Mccullough, Peter A; Tecson, Kristen M. - In: CRITICAL CARE EXPLORATIONS. - ISSN 2639-8028. - 2:9(2020). [10.1097/CCE.0000000000000220]

Inpatient mortality according to level of respiratory support received for severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) infection. a prospective multicenter study

Ruberto, Franco;Mancone, Massimo;Birtolo, Lucia I;Alessandri, Francesco;Infusino, Fabio;Pugliese, Francesco;Fedele, Francesco;
2020

Abstract

Objectives: To describe patients according to the maximum degree of respiratory support received and report their inpatient mortality due to coronavirus disease 2019.Design: Analysis of patients in the Coracle registry from February 22, 2020, to April 1, 2020.Setting: Hospitals in the Piedmont, Lombardy, Tuscany, and Lazio regions of Italy.Patients: Nine-hundred forty-eight patients hospitalized for coronavirus disease 2019.Interventions: None.Measurements and Main Results: Among 948 patients, 122 (12.87%) received invasive ventilation, 637 (67.19%) received supplemental oxygen only, and 189 (19.94%) received no respiratory support. The median (quartile 1-quartile 3) age was 65 years (54-76.59 yr), and there was evidence of differential respiratory treatment by decade of life (p = 0.0046); patients greater than 80 years old were generally not intubated. There were 606 men (63.9%) in this study, and they were more likely to receive respiratory support than women (p < 0.0001). The rate of in-hospital death for invasive ventilation recipients was 22.95%, 12.87% for supplemental oxygen recipients, and 7.41% for those who received neither (p = 0.0004). A sensitivity analysis of the 770 patients less than 80 years old revealed a lower, but similar mortality trend (18.02%, 8.10%, 5.23%; p = 0.0008) among the 14.42%, 65.71%, and 19.87% of patients treated with mechanical ventilation, supplemental oxygen only, or neither. Overall, invasive ventilation recipients who died were significantly older than those who survived (median age: 68.5 yr [60-81.36 yr] vs 62.5 yr [55.52-71 yr]; p = 0.0145).Conclusions: Among patients hospitalized for coronavirus disease 2019, 13% received mechanical ventilation, which was associated with a mortality rate of 23%.
2020
coronavirus disease 2019; inpatient mortality; invasive ventilation; respiratory support; severe acute respiratory syndrome coronavirus 2; supplemental oxygen
01 Pubblicazione su rivista::01a Articolo in rivista
Inpatient mortality according to level of respiratory support received for severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019) infection. a prospective multicenter study / Palazzuoli, Alberto; Ruberto, Franco; De Ferrari, Gaetano M; Forleo, Giovanni; Secco, Gioel G; Ruocco, Gaetano M; D'Ascenzo, Fabrizio; Mojoli, Francesco; Monticone, Silvia; Paggi, Anita; Vicenzi, Marco; Corcione, Silvia; Palazzo, Anna G; Landolina, Maurizio; Taravelli, Erika; Tavazzi, Guido; Blasi, Francesco; Mancone, Massimo; Birtolo, Lucia I; Alessandri, Francesco; Infusino, Fabio; Pugliese, Francesco; Fedele, Francesco; De Rosa, Francesco Giuseppe; Emmett, Michael; Schussler, Jeffrey M; Mccullough, Peter A; Tecson, Kristen M. - In: CRITICAL CARE EXPLORATIONS. - ISSN 2639-8028. - 2:9(2020). [10.1097/CCE.0000000000000220]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1513114
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