Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure.

Malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia / Ciacciarelli, M.; Caruso, G.; Rengo, M.; Maceroni, P.; Misurale, C.; D'Armiento, E.; Polidoro, A.; Napoli, C.; Lombardini, A.; Ceratti, U.; Colunga Biancatelli, R. M. L.; Calvosa, L.; Milanese, R.; Ferri, S.; Massaro, T.; Lorusso, A.; Sorrentino, V.; Petrozza, V.; Iuliano, L.. - In: CASE REPORTS IN ENDOCRINOLOGY. - ISSN 2090-6501. - 2020:(2020). [10.1155/2020/4239679]

Malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia

Ciacciarelli M.
;
Rengo M.;Maceroni P.;Misurale C.;D'Armiento E.;Polidoro A.;Napoli C.;Lombardini A.;Ceratti U.;Colunga Biancatelli R. M. L.;Milanese R.;Petrozza V.;Iuliano L.
2020

Abstract

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure.
2020
insulinoma; MDCT
01 Pubblicazione su rivista::01i Case report
Malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia / Ciacciarelli, M.; Caruso, G.; Rengo, M.; Maceroni, P.; Misurale, C.; D'Armiento, E.; Polidoro, A.; Napoli, C.; Lombardini, A.; Ceratti, U.; Colunga Biancatelli, R. M. L.; Calvosa, L.; Milanese, R.; Ferri, S.; Massaro, T.; Lorusso, A.; Sorrentino, V.; Petrozza, V.; Iuliano, L.. - In: CASE REPORTS IN ENDOCRINOLOGY. - ISSN 2090-6501. - 2020:(2020). [10.1155/2020/4239679]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1498187
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