Introduction: Association between persistency of a patent ductus arteriosus (PDA) and morbidity in preterm newborns is still controversial. We aimed to investigate the relation between PDA and morbidity in a large retrospective study. Methods: A case-control study including neonates consecutively admitted to the Neonatal Intensive Care Unit (NICU), with gestational age (GA) < 32 weeks or body birth weight (BW) < 1500 g, over a 5-year period. Newborns were divided into Cases and Controls, according with the presence or absence of a hemodynamically significant PDA (hs-PDA). Results: We enrolled 85 Cases and 193 Controls. Subjects with hs-PDA had significantly (p < 0.001) lower GA (26.7 w, 95%CI 27.1–28.0 vs. 30.1 w, 95%CI 29.7–30.4), BW (1024 g, 95% CI 952–1097 vs. 1310 g 95%CI 1263–1358) and an increased morbidity (60.0% vs. 18.7%). In a sub-group of extremely preterm newborns (GA ≤ 28 weeks and BW ≤ 1000 g), the rate of bronchopulmonary dysplasia (BPD) was significantly increased in Cases (31.7%) compared with Controls (5.9%, p = 0.033). Multivariate analysis showed that morbidity significantly depended on hs-PDA, GA and BW, and that, in extremely preterms, the hs-PDA represented an independent risk factor for BPD. Conclusions: Occurrence of the main morbidities of prematurity depended by hs-PDA, in association with GA, BW, and use of prenatal steroids. In extremely premature babies, hs-PDA is a risk factor for BPD, one of the most important morbidity of prematurity, independently by other confounding variables.

Morbidity associated with patent ductus arteriosus in preterm newborns: a retrospective case-control study / Terrin, Gianluca; Di Chiara, Maria; Boscarino, Giovanni; Metrangolo, Valentina; Faccioli, Francesca; Onestà, Elisa; Giancotti, Antonella; Di Donato, Violante; Cardilli, Viviana; De Curtis, Mario. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 47:1(2021). [10.1186/s13052-021-00956-2]

Morbidity associated with patent ductus arteriosus in preterm newborns: a retrospective case-control study

Terrin, Gianluca
;
Boscarino, Giovanni;Faccioli, Francesca;Giancotti, Antonella;Di Donato, Violante;Cardilli, Viviana;De Curtis, Mario
2021

Abstract

Introduction: Association between persistency of a patent ductus arteriosus (PDA) and morbidity in preterm newborns is still controversial. We aimed to investigate the relation between PDA and morbidity in a large retrospective study. Methods: A case-control study including neonates consecutively admitted to the Neonatal Intensive Care Unit (NICU), with gestational age (GA) < 32 weeks or body birth weight (BW) < 1500 g, over a 5-year period. Newborns were divided into Cases and Controls, according with the presence or absence of a hemodynamically significant PDA (hs-PDA). Results: We enrolled 85 Cases and 193 Controls. Subjects with hs-PDA had significantly (p < 0.001) lower GA (26.7 w, 95%CI 27.1–28.0 vs. 30.1 w, 95%CI 29.7–30.4), BW (1024 g, 95% CI 952–1097 vs. 1310 g 95%CI 1263–1358) and an increased morbidity (60.0% vs. 18.7%). In a sub-group of extremely preterm newborns (GA ≤ 28 weeks and BW ≤ 1000 g), the rate of bronchopulmonary dysplasia (BPD) was significantly increased in Cases (31.7%) compared with Controls (5.9%, p = 0.033). Multivariate analysis showed that morbidity significantly depended on hs-PDA, GA and BW, and that, in extremely preterms, the hs-PDA represented an independent risk factor for BPD. Conclusions: Occurrence of the main morbidities of prematurity depended by hs-PDA, in association with GA, BW, and use of prenatal steroids. In extremely premature babies, hs-PDA is a risk factor for BPD, one of the most important morbidity of prematurity, independently by other confounding variables.
2021
bronchopulmonary dysplasia (BPD); ibuprofen; intraventricular hemorrhage (IVH); mortality; necrotizing enterocolitis (NEC); paracetamol; retinopathy of prematurity (ROP); survival
01 Pubblicazione su rivista::01a Articolo in rivista
Morbidity associated with patent ductus arteriosus in preterm newborns: a retrospective case-control study / Terrin, Gianluca; Di Chiara, Maria; Boscarino, Giovanni; Metrangolo, Valentina; Faccioli, Francesca; Onestà, Elisa; Giancotti, Antonella; Di Donato, Violante; Cardilli, Viviana; De Curtis, Mario. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 47:1(2021). [10.1186/s13052-021-00956-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1480062
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