Recently, an interesting review appeared in Pharmacological Research presented a list of candidate drugs against SARS-CoV-2 and COVID-19 [1]. In the present insight, we highlight novel experimental evidence that the flavanone Naringenin, targeting the endo-lysosomal Two-Pore Channels (TPCs), could be added to the list of potential weapons against SARS-CoV-2 infection and COVID-19 disease.
Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro / Clementi, N.; Scagnolari, C.; D'Amore, A.; Palombi, F.; Criscuolo, E.; Frasca, F.; Pierangeli, A.; Mancini, N.; Antonelli, G.; Clementi, M.; Carpaneto, A.; Filippini, A.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 163:(2021), pp. 1-5. [10.1016/j.phrs.2020.105255]
Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro
Scagnolari C.;Criscuolo E.;Frasca F.;Pierangeli A.;Mancini N.;Antonelli G.;Carpaneto A.;Filippini A.
2021
Abstract
Recently, an interesting review appeared in Pharmacological Research presented a list of candidate drugs against SARS-CoV-2 and COVID-19 [1]. In the present insight, we highlight novel experimental evidence that the flavanone Naringenin, targeting the endo-lysosomal Two-Pore Channels (TPCs), could be added to the list of potential weapons against SARS-CoV-2 infection and COVID-19 disease.| File | Dimensione | Formato | |
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