Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.

Cancer predisposition syndromes and medulloblastoma in the molecular era / Carta, Roberto; Del Baldo, Giada; Miele, Evelina; Po, Agnese; Besharat, Zein Mersini; Nazio, Francesca; Colafati, Giovanna Stefania; Piccirilli, Eleonora; Agolini, Emanuele; Rinelli, Martina; Lodi, Mariachiara; Cacchione, Antonella; Carai, Andrea; Boccuto, Luigi; Ferretti, Elisabetta; Locatelli, Franco; Mastronuzzi, Angela. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 10:(2020). [10.3389/fonc.2020.566822]

Cancer predisposition syndromes and medulloblastoma in the molecular era

Carta, Roberto;Del Baldo, Giada;Miele, Evelina;Po, Agnese;Besharat, Zein Mersini;Agolini, Emanuele;Cacchione, Antonella;Ferretti, Elisabetta;Locatelli, Franco;Mastronuzzi, Angela
2020

Abstract

Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
2020
Medulloblastoma; genetic syndrome; brain tumors
01 Pubblicazione su rivista::01a Articolo in rivista
Cancer predisposition syndromes and medulloblastoma in the molecular era / Carta, Roberto; Del Baldo, Giada; Miele, Evelina; Po, Agnese; Besharat, Zein Mersini; Nazio, Francesca; Colafati, Giovanna Stefania; Piccirilli, Eleonora; Agolini, Emanuele; Rinelli, Martina; Lodi, Mariachiara; Cacchione, Antonella; Carai, Andrea; Boccuto, Luigi; Ferretti, Elisabetta; Locatelli, Franco; Mastronuzzi, Angela. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 10:(2020). [10.3389/fonc.2020.566822]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1449516
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