Objective. To better understand the real prevalence of cutaneous manifestations, in Neurofibromatosis type 1. Materials and Methods. We reviewed all clinical charts of 1102 NF1 patients followed by February 1983 to February 2020 at the “Sapienza” University of Rome, Italy. NF1 patients are seen usually every year by a dermatologist. Results. Café-au-lait macules were shown in 1063 patients (96.5%), axillary and inguinal freckling in 991 (90%) and neurofibromas in 861 (78.1%). Other skin manifestations included: lipoma (6.2%), nevus anemicus (3.9%), psoriasis (3.4%), spilus nevus (3.2%), juvenile xanthogranuloma (3.2%), vitiligo (2.3%), Becker's nevus (1.9%), melanoma (0.7%) and poliosis (0.5%). Conclusions. Neurofibromatosis type 1 is a multisystem disorder primarily involving the skin and nervous system. The clinical manifestations are extremely variable even within a family. This study was performed to delineate the prevalence of cutaneous manifestations in NF1.

Cutaneous manifestations in neurofibromatosis type 1 / Miraglia, E.; Moliterni, E.; Iacovino, C.; Roberti, V.; Laghi, A.; Moramarco, A.; Giustini, S.. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 171:5(2020), pp. 371-377. [10.7417/CT.2020.2242]

Cutaneous manifestations in neurofibromatosis type 1

Miraglia E.
Primo
;
Moliterni E.
Secondo
;
Iacovino C.;Roberti V.;Laghi A.;Moramarco A.
Penultimo
;
Giustini S.
Ultimo
2020

Abstract

Objective. To better understand the real prevalence of cutaneous manifestations, in Neurofibromatosis type 1. Materials and Methods. We reviewed all clinical charts of 1102 NF1 patients followed by February 1983 to February 2020 at the “Sapienza” University of Rome, Italy. NF1 patients are seen usually every year by a dermatologist. Results. Café-au-lait macules were shown in 1063 patients (96.5%), axillary and inguinal freckling in 991 (90%) and neurofibromas in 861 (78.1%). Other skin manifestations included: lipoma (6.2%), nevus anemicus (3.9%), psoriasis (3.4%), spilus nevus (3.2%), juvenile xanthogranuloma (3.2%), vitiligo (2.3%), Becker's nevus (1.9%), melanoma (0.7%) and poliosis (0.5%). Conclusions. Neurofibromatosis type 1 is a multisystem disorder primarily involving the skin and nervous system. The clinical manifestations are extremely variable even within a family. This study was performed to delineate the prevalence of cutaneous manifestations in NF1.
2020
café-au-lait macules; cutaneous manifestations; freckling; neurofibroma; neurofibromatosis type 1; neurofibromin
01 Pubblicazione su rivista::01i Case report
Cutaneous manifestations in neurofibromatosis type 1 / Miraglia, E.; Moliterni, E.; Iacovino, C.; Roberti, V.; Laghi, A.; Moramarco, A.; Giustini, S.. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 171:5(2020), pp. 371-377. [10.7417/CT.2020.2242]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1443782
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