Over the past two decades, there have been two major outbreaks where the crossover of animal Betacoronaviruses to humans has resulted in severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In December 2019, a global public health concern started with the emergence of a new strain of coronavirus (SARS-CoV-2 or 2019 novel coronavirus, 2019-nCoV) which has rapidly spread all over the world from its origin in Wuhan, China. SARS-CoV-2 belongs to the Betacoronavirus genus, which includes human SARS-CoV, MERS and two other human coronaviruses (HCoVs), HCoV-OC43 and HCoV-HKU1. The fatality rate of SARS-CoV-2 is lower than the two previous coronavirus epidemics, but it is faster spreading and the large number of infected people with severe viral pneumonia and respiratory illness, showed SARS-CoV-2 to be highly contagious. Based on the current published evidence, herein we summarize the origin, genetics, epidemiology, clinical manifestations, preventions, diagnosis and up to date treatments of SARS-CoV-2 infections in comparison with those caused by SARS-CoV and MERS-CoV. Moreover, the possible impact of weather conditions on the transmission of SARS-CoV-2 is also discussed. Therefore, the aim of the present review is to reconsider the two previous pandemics and provide a reference for future studies as well as therapeutic approaches.

The global emergency of novel coronavirus (SARS-CoV-2). An update of the current status and forecasting / Hozhabri, Hossein; PICECI SPARASCIO, Francesca; Sohrabi, Hamidreza; Mousavifar, Leila; Roy, René; Scribano, Daniela; De Luca, Alessandro; AMBROSI SACCONI ROSATI, Cecilia; Sarsharjeryandeh, Meysam. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 17:16(2020), pp. 1-34. [10.3390/ijerph17165648]

The global emergency of novel coronavirus (SARS-CoV-2). An update of the current status and forecasting

Hossein Hozhabri;Francesca Piceci Sparascio;Daniela Scribano;Cecilia Ambrosi;Meysam Sarshar
2020

Abstract

Over the past two decades, there have been two major outbreaks where the crossover of animal Betacoronaviruses to humans has resulted in severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In December 2019, a global public health concern started with the emergence of a new strain of coronavirus (SARS-CoV-2 or 2019 novel coronavirus, 2019-nCoV) which has rapidly spread all over the world from its origin in Wuhan, China. SARS-CoV-2 belongs to the Betacoronavirus genus, which includes human SARS-CoV, MERS and two other human coronaviruses (HCoVs), HCoV-OC43 and HCoV-HKU1. The fatality rate of SARS-CoV-2 is lower than the two previous coronavirus epidemics, but it is faster spreading and the large number of infected people with severe viral pneumonia and respiratory illness, showed SARS-CoV-2 to be highly contagious. Based on the current published evidence, herein we summarize the origin, genetics, epidemiology, clinical manifestations, preventions, diagnosis and up to date treatments of SARS-CoV-2 infections in comparison with those caused by SARS-CoV and MERS-CoV. Moreover, the possible impact of weather conditions on the transmission of SARS-CoV-2 is also discussed. Therefore, the aim of the present review is to reconsider the two previous pandemics and provide a reference for future studies as well as therapeutic approaches.
2020
sars-cov-2; epidemiology; transmission; temperature and humidity; covid-19; pneumonia; diagnosis; ace2; inhibitors; therapeutics strategies
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
The global emergency of novel coronavirus (SARS-CoV-2). An update of the current status and forecasting / Hozhabri, Hossein; PICECI SPARASCIO, Francesca; Sohrabi, Hamidreza; Mousavifar, Leila; Roy, René; Scribano, Daniela; De Luca, Alessandro; AMBROSI SACCONI ROSATI, Cecilia; Sarsharjeryandeh, Meysam. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 17:16(2020), pp. 1-34. [10.3390/ijerph17165648]
File allegati a questo prodotto
File Dimensione Formato  
Hozhabri_global emergency_2020.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 2.62 MB
Formato Adobe PDF
2.62 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1441084
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 44
  • ???jsp.display-item.citation.isi??? 36
social impact