Objectives: To evaluate expansion of CD21low B cells and their role in B cell homeostasis, apoptosis, clinical manifestations and serum vascular endothelial growth factor (VEGF) in systemic sclerosis (SSc). Materials and methods: B-cells subpopulations and apoptosis have been assessed in 74 SSc patients and 20 healthy donors. Renal Doppler ultrasound, echocardiography, pulmonary function test and VEGF were performed. Results: SSc patients with expanded CD21low B cells (SSc-CD21low) show a distinct B cell profile with increased memory B cells compared to patients without CD21low B cells (SSc-CD21+). Renal resistive index, systolic pulmonary arterial pressure and FVC/DLCO ratio were significantly higher in SSc-CD21low group than SSc-CD21+, DLCO was lower in SSc-CD21low group than SSc-CD21+. We found a positive linear correlation between CD21low and sPAP, RI and FVC/DLCO ratio whereas a negative correlation was observed between CD21low and DLCO and VEGF levels. Conclusions: CD21low B cells are increased in SSc patients with visceral vascular manifestations.

CD21low B cells in systemic sclerosis: a possible marker of vascular complications / Marrapodi, R.; Pellicano, C.; Radicchio, G.; Leodori, G.; Colantuono, S.; Iacolare, A.; Gigante, A.; Visentini, M.; Rosato, E.. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 213:(2020). [10.1016/j.clim.2020.108364]

CD21low B cells in systemic sclerosis: a possible marker of vascular complications

Marrapodi R.;Pellicano C.;Radicchio G.;Leodori G.;Colantuono S.;Iacolare A.;Gigante A.;Visentini M.;Rosato E.
2020

Abstract

Objectives: To evaluate expansion of CD21low B cells and their role in B cell homeostasis, apoptosis, clinical manifestations and serum vascular endothelial growth factor (VEGF) in systemic sclerosis (SSc). Materials and methods: B-cells subpopulations and apoptosis have been assessed in 74 SSc patients and 20 healthy donors. Renal Doppler ultrasound, echocardiography, pulmonary function test and VEGF were performed. Results: SSc patients with expanded CD21low B cells (SSc-CD21low) show a distinct B cell profile with increased memory B cells compared to patients without CD21low B cells (SSc-CD21+). Renal resistive index, systolic pulmonary arterial pressure and FVC/DLCO ratio were significantly higher in SSc-CD21low group than SSc-CD21+, DLCO was lower in SSc-CD21low group than SSc-CD21+. We found a positive linear correlation between CD21low and sPAP, RI and FVC/DLCO ratio whereas a negative correlation was observed between CD21low and DLCO and VEGF levels. Conclusions: CD21low B cells are increased in SSc patients with visceral vascular manifestations.
2020
B cells; CD21; low; kidney; pulmonary arterial hypertension; systemic sclerosis
01 Pubblicazione su rivista::01a Articolo in rivista
CD21low B cells in systemic sclerosis: a possible marker of vascular complications / Marrapodi, R.; Pellicano, C.; Radicchio, G.; Leodori, G.; Colantuono, S.; Iacolare, A.; Gigante, A.; Visentini, M.; Rosato, E.. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 213:(2020). [10.1016/j.clim.2020.108364]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1377143
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