Pleomorphic adenoma is a common benign salivary gland tumor, which represents about 66 % of benign neoplasms of the salivary glands. Although it can occur in any salivary gland, it is most frequently found in the parotid. Pleomorphic adenomas are renowned for their cytomorphological and architectural heterogeneity that are characterized by intermixed epithelial and mesenchymallike components. We report a rare case of pleomorphic adenoma of the parotid gland with prevalent schwannomalike features mimicking a benign schwannoma. Microscopically the tumor showed a prevalence (about 95 %) of schwannoma-like areas with focal (about 5 %) epithelial component with tubular organization. The tumor showed positive immunoexpression for cytokeratin, S-100 protein, and focal expression of p63, CD10 and smooth muscle actin. To the best of our knowledge only six cases of schwannoma-like pleomorphic adenoma have been reported in the literature. The differential diagnosis between this entity and neurogenic and myogenic tumors is discussed.

Schwannoma-like pleomorphic adenoma. a case report with review of the literature.Head Neck Pathol / Lombardi, Mariangela; Socciarelli, Fabio; Fini, Giuseppina; Leonardi, Alessandra; Bartolazzi, Armando. - In: HEAD AND NECK PATHOLOGY. - ISSN 1936-055X. - 8:2(2014), pp. 178-181. [10.1007/s12105-013-0473-9]

Schwannoma-like pleomorphic adenoma. a case report with review of the literature.Head Neck Pathol

Mariangela Lombardi;Fabio Socciarelli;Giuseppina Fini;Armando Bartolazzi
2014

Abstract

Pleomorphic adenoma is a common benign salivary gland tumor, which represents about 66 % of benign neoplasms of the salivary glands. Although it can occur in any salivary gland, it is most frequently found in the parotid. Pleomorphic adenomas are renowned for their cytomorphological and architectural heterogeneity that are characterized by intermixed epithelial and mesenchymallike components. We report a rare case of pleomorphic adenoma of the parotid gland with prevalent schwannomalike features mimicking a benign schwannoma. Microscopically the tumor showed a prevalence (about 95 %) of schwannoma-like areas with focal (about 5 %) epithelial component with tubular organization. The tumor showed positive immunoexpression for cytokeratin, S-100 protein, and focal expression of p63, CD10 and smooth muscle actin. To the best of our knowledge only six cases of schwannoma-like pleomorphic adenoma have been reported in the literature. The differential diagnosis between this entity and neurogenic and myogenic tumors is discussed.
2014
schwannoma-like pleomorphic adenoma; pleomorphic adenoma; mixed tumors
01 Pubblicazione su rivista::01i Case report
Schwannoma-like pleomorphic adenoma. a case report with review of the literature.Head Neck Pathol / Lombardi, Mariangela; Socciarelli, Fabio; Fini, Giuseppina; Leonardi, Alessandra; Bartolazzi, Armando. - In: HEAD AND NECK PATHOLOGY. - ISSN 1936-055X. - 8:2(2014), pp. 178-181. [10.1007/s12105-013-0473-9]
File allegati a questo prodotto
File Dimensione Formato  
Lombardi_Schwannoma-like_2014.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.91 MB
Formato Adobe PDF
1.91 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1351402
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 10
  • ???jsp.display-item.citation.isi??? ND
social impact