Collective properties of biological neuronal network

A primary challenge of neuroscience is to clear up how neurons, organized in the massive neural networks of the brain, communicate and dynamically regulate their connections to give rise to higher brain functions. The aim of this thesis was to combine a custom-made high-resolution wide-field calcium imaging setup and personalized data analysis algorithms, in order to investigate cortical emergent rhythms and provide insights into the microscopic network mechanisms underlying associated network activity alterations in 3xTg-AD strain derived cortical networks.