Purpose: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles. Methods: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation. Results: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%. Conclusions: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.

Characterisation of a β detector on positron emitters for medical applications / Collamati, F.; Moretti, R.; Alunni-Solestizi, L.; Bocci, V.; Cartoni, A.; Collarino, A.; De Simoni, M.; Faccini, R.; Fischetti, M.; Giordano, A.; Maccora, D.; Mancini-Terracciano, C.; Mirabelli, R.; Scotognella, T.; Solfaroli-Camillocci, E.; Traini, G.; Morganti, S.. - In: PHYSICA MEDICA. - ISSN 1120-1797. - 67(2019), pp. 85-90. [10.1016/j.ejmp.2019.10.025]

Characterisation of a β detector on positron emitters for medical applications

Cartoni A.;De Simoni M.;Faccini R.;Fischetti M.;Mancini-Terracciano C.;Mirabelli R.;Solfaroli-Camillocci E.
;
2019

Abstract

Purpose: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio tracers, overtakes some limitations of established γ-RGS. In this context, a first prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, has been developed and characterised on pure β- emitters, like 90Y. The demonstrated very high efficiency to β- particles, together with the remarkable transparency to photons, suggested the possibility to use this detector also with β+ emitting sources, that have plenty of applications in nuclear medicine. In this paper, we present upgrades and optimisations performed to the detector to reveal such particles. Methods: Laboratory measurement have been performed on liquid Ga68 source, and were used to validate and tune a Monte Carlo simulation. Results: The upgraded detector has an ~80% efficiency to electrons above ~110keV, reaching a plateau value of ~95%. At the same time, the probe is substantially transparent to photons below ~200keV, reaching a plateau value of ~3%. Conclusions: The new prototype seems to have promising characteristics to perform RGS also with β+ emitting isotopes.
File allegati a questo prodotto
File Dimensione Formato  
Collamati_Positron-emitter_2019.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 921.45 kB
Formato Adobe PDF
921.45 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1339851
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact