Self-assembly process of a well-defined structures from various chemical building blocks have found exponential growth in the development of drug delivery and bionanotechnology systems.1 In particular, these assemblies give the possibility to encapsulate a pharmaceutically active compound in their core (or at their surface) and to cargo this compound to its therapeutic target.2 Self-assembly can include different levels of complexity: it can be as simple as the dimerization of two small building blocks driven by hydrogen bonding or as complicated as a cell membrane, a remarkable supramolecular architecture created by a bilayer of phospholipids embedded with functional proteins. In addition to a vast series of natural amphiphilic structures, a number of ‘‘engineered’’ synthetic architectures have been designed, using a macrocyclic core such as cyclodextrins and crown-ethers.2 Thus, the versatility of calixarene-based macrocycles could represent promising building blocks to design amphiphiles.

From Macrocycles to Molecular Shuttles: Exploring the Supramolecular Assembly of Resorc[4]arenes / Quaglio, D.; Buonsenso, F.; Calcaterra, A.; Ghirga, F.; Balducci, S.; Botta, B.; Pierini, M.. - (2019). ((Intervento presentato al convegno 14th International Symposium on Macrocyclic and Supramolecular Chemistry tenutosi a Lecce.

From Macrocycles to Molecular Shuttles: Exploring the Supramolecular Assembly of Resorc[4]arenes

D. Quaglio
Primo
;
F. Buonsenso
Secondo
;
A. Calcaterra;F. Ghirga;S. Balducci;B. Botta;M. Pierini
2019

Abstract

Self-assembly process of a well-defined structures from various chemical building blocks have found exponential growth in the development of drug delivery and bionanotechnology systems.1 In particular, these assemblies give the possibility to encapsulate a pharmaceutically active compound in their core (or at their surface) and to cargo this compound to its therapeutic target.2 Self-assembly can include different levels of complexity: it can be as simple as the dimerization of two small building blocks driven by hydrogen bonding or as complicated as a cell membrane, a remarkable supramolecular architecture created by a bilayer of phospholipids embedded with functional proteins. In addition to a vast series of natural amphiphilic structures, a number of ‘‘engineered’’ synthetic architectures have been designed, using a macrocyclic core such as cyclodextrins and crown-ethers.2 Thus, the versatility of calixarene-based macrocycles could represent promising building blocks to design amphiphiles.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1337016
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