The exposition to megasonic fields can induce several biological effects with potential damage for human health. The more significant ones involve membrane poration, with the consequent permeabilization of cells to exogenous particles and the triggering of inflammatory and cytotoxic processes. We developed an experimental setup with the purpose to perform an in vitro systematic analysis of the biological effects related to the ultrasound-cell interaction. Our study involved two using different cell models, human keratinocyte (HaCaT) and skin melanoma (SK-Mel28). The ultrasound-induced biological effects have been investigated at two frequencies (0.5 MHz and 1 MHz) as a function of different exposure parameters.
In vitro analysis of the mechanical and biological effects induced by the ultrasound-cell interaction / Brasili, F.; Giantulli, S.; Palmieri, E. Tortorella D.; Bedini, A.; Morrone, S.; Silvestri, I.; Domenici, G. Paradossi and F.. - (2019). (Intervento presentato al convegno Biophysics@Rome2019 tenutosi a Rome; Italy).
In vitro analysis of the mechanical and biological effects induced by the ultrasound-cell interaction
F. Brasili
;S. Giantulli;S. Morrone;
2019
Abstract
The exposition to megasonic fields can induce several biological effects with potential damage for human health. The more significant ones involve membrane poration, with the consequent permeabilization of cells to exogenous particles and the triggering of inflammatory and cytotoxic processes. We developed an experimental setup with the purpose to perform an in vitro systematic analysis of the biological effects related to the ultrasound-cell interaction. Our study involved two using different cell models, human keratinocyte (HaCaT) and skin melanoma (SK-Mel28). The ultrasound-induced biological effects have been investigated at two frequencies (0.5 MHz and 1 MHz) as a function of different exposure parameters.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
