The construct of physical frailty and sarcopenia (PF&S) identifies an age-related pre-disability condition defined by reduced physical performance and low muscle mass. Whether PF&S is characterized by perturbations of the cytokine network is presently unclear. Furthermore, the existence of gender-specific inflammatory profiles of PF&S is unknown. This study was designed to explore the association between a large panel of inflammatory biomolecules and PF&S in older adults through a multivariate statistical approach. Gender-specific inflammatory patterns were also explored.

Inflammatory signatures in older persons with physical frailty and sarcopenia. the frailty "cytokinome" at its core / Marzetti, Emanuele; Picca, Anna; Marini, Federico; Biancolillo, Alessandra; Coelho-Junior, Hélio José; Gervasoni, Jacopo; Bossola, Maurizio; Cesari, Matteo; Onder, Graziano; Landi, Francesco; Bernabei, Roberto; Calvani, Riccardo. - In: EXPERIMENTAL GERONTOLOGY. - ISSN 0531-5565. - 122:(2019), pp. 129-138. [10.1016/j.exger.2019.04.019]

Inflammatory signatures in older persons with physical frailty and sarcopenia. the frailty "cytokinome" at its core

Marini, Federico;Biancolillo, Alessandra;Onder, Graziano;LANDI, Francesco;
2019

Abstract

The construct of physical frailty and sarcopenia (PF&S) identifies an age-related pre-disability condition defined by reduced physical performance and low muscle mass. Whether PF&S is characterized by perturbations of the cytokine network is presently unclear. Furthermore, the existence of gender-specific inflammatory profiles of PF&S is unknown. This study was designed to explore the association between a large panel of inflammatory biomolecules and PF&S in older adults through a multivariate statistical approach. Gender-specific inflammatory patterns were also explored.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1280973
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