The ability to merge electronic devices with biological systems at the cellular scale is an interesting perspective. Potential applications span from investigating the bio-electric signals in excitable (and non-excitable) cells with an insofar-unreached resolution to plan next-generation therapeutic devices. Semiconductor nanowires (NWs) are well suited for achieving this goal because of their intrinsic size and wide range of possible configurations. However, production of such nanoscale electrodes is pricey, time-consuming and affected by poor compatibility with the Complementary Metal-Oxide-Semiconductor integrated circuits (CMOS-IC) process standards. To take a step forward, we introduced a new method to fabricate small, high-density Silicon NWs (SiNWs) with a fast, relatively inexpensive and low-temperature (200 °C) process. Growth of such SiNWs is compatible with CMOS-IC standards, thus theoretically allowing on-site amplification of bioelectric signals from living cells in tight contact. Here, we report our preliminary data showing the biocompatibility of such SiNWs, as a necessary step to produce a compact device providing super-resolved descriptions of bioelectric waveforms captured from the subcellular to the network level.

Silicon nanowires to detect electric signals from living cells / Piedimonte, Paola; Mazzetta, Ivan; Fucile, Sergio; Limatola, Cristina; Cattaruzza, Elti; Riello, Pietro; Renzi, Massimiliano; Palma, Fabrizio. - In: MATERIALS RESEARCH EXPRESS. - ISSN 2053-1591. - 6:8(2019). [10.1088/2053-1591/ab20f8]

Silicon nanowires to detect electric signals from living cells

Piedimonte, Paola;Mazzetta, Ivan;Fucile, Sergio;Limatola, Cristina;Renzi, Massimiliano
;
Palma, Fabrizio
2019

Abstract

The ability to merge electronic devices with biological systems at the cellular scale is an interesting perspective. Potential applications span from investigating the bio-electric signals in excitable (and non-excitable) cells with an insofar-unreached resolution to plan next-generation therapeutic devices. Semiconductor nanowires (NWs) are well suited for achieving this goal because of their intrinsic size and wide range of possible configurations. However, production of such nanoscale electrodes is pricey, time-consuming and affected by poor compatibility with the Complementary Metal-Oxide-Semiconductor integrated circuits (CMOS-IC) process standards. To take a step forward, we introduced a new method to fabricate small, high-density Silicon NWs (SiNWs) with a fast, relatively inexpensive and low-temperature (200 °C) process. Growth of such SiNWs is compatible with CMOS-IC standards, thus theoretically allowing on-site amplification of bioelectric signals from living cells in tight contact. Here, we report our preliminary data showing the biocompatibility of such SiNWs, as a necessary step to produce a compact device providing super-resolved descriptions of bioelectric waveforms captured from the subcellular to the network level.
2019
silicon nanowires; bioelectric signal; XRD; Chemical Vapor Deposition; biosensing
01 Pubblicazione su rivista::01a Articolo in rivista
Silicon nanowires to detect electric signals from living cells / Piedimonte, Paola; Mazzetta, Ivan; Fucile, Sergio; Limatola, Cristina; Cattaruzza, Elti; Riello, Pietro; Renzi, Massimiliano; Palma, Fabrizio. - In: MATERIALS RESEARCH EXPRESS. - ISSN 2053-1591. - 6:8(2019). [10.1088/2053-1591/ab20f8]
File allegati a questo prodotto
File Dimensione Formato  
Piedimonte_pre-print_Silicon-nanowires_2019.pdf

Open Access dal 26/05/2020

Note: DOI: 10.1088/2053-1591/ab20f8
Tipologia: Documento in Pre-print (manoscritto inviato all'editore, precedente alla peer review)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 4.77 MB
Formato Adobe PDF
4.77 MB Adobe PDF
Piedimonte_Silicon-nanowires_2019.pdf

Open Access dal 26/05/2020

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.13 MB
Formato Adobe PDF
1.13 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1277776
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 0
social impact