The new immunotherapy targeting the programmed cell death 1 (PD-1) receptor and its cognate ligand PD-L1 has renewed hopes of eradicating the most difficult human cancers to treat. Among these, there are the poorly differentiated and anaplastic thyroid cancers, unresponsive to all the therapies currently in use. In the present review we will summarize information regarding the expression of PD-L1 in the different thyroid cancer histotypes, its correlation with clinicopathological features, and its potential prognostic value. Then, we will evaluate the available data indicating the PD-1/PD-L1 axis as a promising target for thyroid cancer therapy.

PD-1 ligand expression in epithelial thyroid cancers. Potential clinical implications / Ulisse, Salvatore; Tuccilli, Chiara; Sorrenti, Salvatore; Antonelli, Alessandro; Fallahi, Poupak; D’Armiento, Eleonora; Catania, Antonio; Tartaglia, Francesco; Amabile, Maria Ida; Giacomelli, Laura; Metere, Alessio; Cornacchini, Nicola; Pironi, Daniele; Carbotta, Giovanni; Vergine, Massimo; Monti, Massimo; Baldini, Enke. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 20:6(2019). [10.3390/ijms20061405]

PD-1 ligand expression in epithelial thyroid cancers. Potential clinical implications

Ulisse, Salvatore;Tuccilli, Chiara;Sorrenti, Salvatore;D’armiento, Eleonora;Catania, Antonio;Tartaglia, Francesco;Amabile, Maria Ida;Giacomelli, Laura;Metere, Alessio;Pironi, Daniele;Carbotta, Giovanni;Vergine, Massimo;Monti, Massimo;Baldini, Enke
2019

Abstract

The new immunotherapy targeting the programmed cell death 1 (PD-1) receptor and its cognate ligand PD-L1 has renewed hopes of eradicating the most difficult human cancers to treat. Among these, there are the poorly differentiated and anaplastic thyroid cancers, unresponsive to all the therapies currently in use. In the present review we will summarize information regarding the expression of PD-L1 in the different thyroid cancer histotypes, its correlation with clinicopathological features, and its potential prognostic value. Then, we will evaluate the available data indicating the PD-1/PD-L1 axis as a promising target for thyroid cancer therapy.
2019
Diagnosis; Prognosis; Programmed cell death 1; Programmed cell death ligand 1; Therapy; Thyroid cancer.
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
PD-1 ligand expression in epithelial thyroid cancers. Potential clinical implications / Ulisse, Salvatore; Tuccilli, Chiara; Sorrenti, Salvatore; Antonelli, Alessandro; Fallahi, Poupak; D’Armiento, Eleonora; Catania, Antonio; Tartaglia, Francesco; Amabile, Maria Ida; Giacomelli, Laura; Metere, Alessio; Cornacchini, Nicola; Pironi, Daniele; Carbotta, Giovanni; Vergine, Massimo; Monti, Massimo; Baldini, Enke. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 20:6(2019). [10.3390/ijms20061405]
File allegati a questo prodotto
File Dimensione Formato  
Ulisse_PD-1-ligand_2019.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 514.57 kB
Formato Adobe PDF
514.57 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1264641
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 34
social impact