Substrate-selectivity stemming from recognition is a key feature of enzymes that has been seldom observed in artificial catalysts. Herein, we report a recognition-driven, substrate-selective C-H oxidation that inverts the intrinsic reactivity of the competing C-H bonds. Analysis of this selectivity highlights an unexpectedly high reactivity enhancement imparted by intramolecularity. © 2019 The Royal Society of Chemistry.
Enzyme-like substrate-selectivity in C-H oxidation enabled by recognition / Olivo, Giorgio; Capocasa, Giorgio; Lanzalunga, Osvaldo; DI STEFANO, Stefano; Costas, Miquel. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 55:7(2019), pp. 917-920. [10.1039/c8cc09328h]
Enzyme-like substrate-selectivity in C-H oxidation enabled by recognition
Olivo, Giorgio
;Capocasa, Giorgio;Lanzalunga, Osvaldo;Di Stefano, Stefano
;
2019
Abstract
Substrate-selectivity stemming from recognition is a key feature of enzymes that has been seldom observed in artificial catalysts. Herein, we report a recognition-driven, substrate-selective C-H oxidation that inverts the intrinsic reactivity of the competing C-H bonds. Analysis of this selectivity highlights an unexpectedly high reactivity enhancement imparted by intramolecularity. © 2019 The Royal Society of Chemistry.| File | Dimensione | Formato | |
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Olivo_Enzyme_2019.pdf
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