Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexist- ing glomerulonephritis. We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Nasal endoscopy showed a large nasal septum perforation and an anterior translucid mass in the right nasal fossa. Findings were confirmed by computed tomography (CT) scan with contrast. The patient underwent func- tional transnasal endoscopic removal of the mass; histological examination showed tissue features suggestive of GPA; dosage of c-ANCA e p-ANCA antibodies confirmed GPA diagnosis. Nasal septum perforation has long been recognized as a feature of GPA, in which granulomatous destruction of nasal cartilage can result in perforation and saddle-nose deformity. Prompt diagno- sis of GPA is important to initiate therapy which may be life-saving and organ sparing.

Nasal manifestations in granulomatosis with polyangiitis: a case report and review of the literature / Ralli, Massimo; D'Aguanno, Vittorio; Falasca, Vincenzo; Turchetta, Rosaria; Greco, Antonio; DE VINCENTIIS, Marco. - In: OTOLARYNGOLOGY OPEN ACCESS JOURNAL. - ISSN 2476-2490. - 4:1(2018), pp. 22-25. [10.17140/OTLOJ-4-149]

Nasal manifestations in granulomatosis with polyangiitis: a case report and review of the literature

Massimo Ralli
Primo
;
Vittorio D’ Aguanno
Secondo
;
Vincenzo Falasca;Rosaria Turchetta;Antonio Greco
Penultimo
;
Marco de Vincentiis
Ultimo
2018

Abstract

Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexist- ing glomerulonephritis. We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Nasal endoscopy showed a large nasal septum perforation and an anterior translucid mass in the right nasal fossa. Findings were confirmed by computed tomography (CT) scan with contrast. The patient underwent func- tional transnasal endoscopic removal of the mass; histological examination showed tissue features suggestive of GPA; dosage of c-ANCA e p-ANCA antibodies confirmed GPA diagnosis. Nasal septum perforation has long been recognized as a feature of GPA, in which granulomatous destruction of nasal cartilage can result in perforation and saddle-nose deformity. Prompt diagno- sis of GPA is important to initiate therapy which may be life-saving and organ sparing.
granulomatosis with polyangiitis; nasal septum perforation; nasal polyp; vasculitis
01 Pubblicazione su rivista::01i Case report
Nasal manifestations in granulomatosis with polyangiitis: a case report and review of the literature / Ralli, Massimo; D'Aguanno, Vittorio; Falasca, Vincenzo; Turchetta, Rosaria; Greco, Antonio; DE VINCENTIIS, Marco. - In: OTOLARYNGOLOGY OPEN ACCESS JOURNAL. - ISSN 2476-2490. - 4:1(2018), pp. 22-25. [10.17140/OTLOJ-4-149]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1210338
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