We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma.

CYTOGENETIC FINDINGS IN 20 MELANOMAS / Grammatico, Paola; Catricala, C.; Potenza, C.; Amantea, A.; Roccella, M.; Roccella, F.; Eibenschutz, ; DEL PORTO, Giuseppe. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - STAMPA. - 3:3(1993), pp. 169-172. [10.1097/00008390-199306000-00004]

CYTOGENETIC FINDINGS IN 20 MELANOMAS

GRAMMATICO, Paola;C. Potenza;DEL PORTO, Giuseppe
1993

Abstract

We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma.
1993
chromosomal marker; clinical characterization; cytogenetics; melanoma
01 Pubblicazione su rivista::01a Articolo in rivista
CYTOGENETIC FINDINGS IN 20 MELANOMAS / Grammatico, Paola; Catricala, C.; Potenza, C.; Amantea, A.; Roccella, M.; Roccella, F.; Eibenschutz, ; DEL PORTO, Giuseppe. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - STAMPA. - 3:3(1993), pp. 169-172. [10.1097/00008390-199306000-00004]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/117815
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 12
social impact