Treatment of leukemia cells with 1,25-dihydroxyvitamin D3 may overcome their differentiation block and lead to the transition from myeloblasts to monocytes. To identify microRNA-mRNA networks relevant for myeloid differentiation, we profiled the expression of mRNAs and microRNAs associated to the low- and high-density ribosomal fractions in leukemic cells and in their differentiated monocytic counterpart. Intersection between mRNAs shifted across the fractions after treatment with putative target genes of modulated microRNAs showed a series of molecular networks relevant for the monocyte cell fate determination, as for example the post-transcriptional regulation of the Polo-like kinase 1 (PLK1) by miR-22–3p and let-7e-5p.
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|Titolo:||Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition|
|Data di pubblicazione:||2015|
|Citazione:||Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition / Fontemaggi, Giulia; Bellissimo, Teresa; Donzelli, Sara; Iosue', Ilaria; Benassi, Barbara; Bellotti, Giorgio; Blandino1, Giovanni; Fazi, Francesco. - (2015).|
|Appartiene alla tipologia:||15a Dataset|