Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition

Giulia, Fontemaggi; Bellissimo, Teresa; Sara, Donzelli; Iosue', Ilaria; Barbara, Benassi; Giorgio, Bellotti; Giovanni, Blandino1; Fazi, Francesco

Treatment of leukemia cells with 1,25-dihydroxyvitamin D3 may overcome their differentiation block and lead to the transition from myeloblasts to monocytes. To identify microRNA-mRNA networks relevant for myeloid differentiation, we profiled the expression of mRNAs and microRNAs associated to the low- and high-density ribosomal fractions in leukemic cells and in their differentiated monocytic counterpart. Intersection between mRNAs shifted across the fractions after treatment with putative target genes of modulated microRNAs showed a series of molecular networks relevant for the monocyte cell fate determination, as for example the post-transcriptional regulation of the Polo-like kinase 1 (PLK1) by miR-22–3p and let-7e-5p.

Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition / Fontemaggi, Giulia; Bellissimo, Teresa; Donzelli, Sara; Iosue', Ilaria; Benassi, Barbara; Bellotti, Giorgio; Blandino1, Giovanni; Fazi, Francesco. - (2015).

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Titolo:	Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition
Autori:	Giulia Fontemaggi BELLISSIMO, TERESA Sara Donzelli IOSUE', ILARIA Barbara Benassi Giorgio Bellotti Giovanni Blandino1 FAZI, Francesco mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Citazione:	Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition / Fontemaggi, Giulia; Bellissimo, Teresa; Donzelli, Sara; Iosue', Ilaria; Benassi, Barbara; Bellotti, Giorgio; Blandino1, Giovanni; Fazi, Francesco. - (2015).
Handle:	http://hdl.handle.net/11573/1167162
Appartiene alla tipologia:	15a Dataset

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