A microbial ecosystem in which bacteria no longer live in a mutualistic association is called dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal illnesses (irritable bowel syndrome, celiac disease, and inflammatory bowel disease) and extra-intestinal illnesses (obesity, metabolic disorder, cardiovascular syndrome, allergy, and asthma). Dysbiosis status has been related to various important pathologies, and many therapeutic strategies aimed at restoring the balance of the intestinal ecosystem have been implemented. These strategies include the administration of probiotics, prebiotics, and synbiotics; phage therapy; fecal transplantation; bacterial consortium transplantation; and a still poorly investigated approach based on predatory bacteria. This review discusses the various aspects of these strategies to counteract intestinal dysbiosis.
Un ecosistema in cui i batteri non vivono più in un'associazione mutualistica è chiamato disbiotico. La disbiosi del microbiota intestinale è una condizione correlabile sia alla patogenesi di alcune malattie intestinali (sindrome dell'intestino irritabile, celiachia e malattia infiammatoria intestinale) che a malattie extra-intestinali (obesità, disturbi metabolici, sindrome cardiovascolare, allergie e asma). Lo stato di disbiosi è stato correlato a varie patologie importanti e sono state implementate molte strategie terapeutiche volte a ripristinare l'equilibrio dell'ecosistema intestinale. Queste strategie includono la somministrazione di probiotici, prebiotici e sinbiotici; terapia dei fagi; trapianto di feci o di consorzi batterici e un approccio ancora poco studiato basato sull’impiego di batteri predatori. Questa recensione analizza i vari aspetti delle molteplici strategie proposte per contrastare la disbiosi intestinale.
Rebuilding the gut microbiota ecosystem / Gagliardi, Antonella; Totino, Valentina; Cacciotti, Fatima; Iebba, Valerio; Neroni, Bruna; Bonfiglio, Giulia; Trancassini, Maria; Passariello, Claudio; Pantanella, Fabrizio; Schippa, Serena. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - ELETTRONICO. - 15:8(2018). [10.3390/ijerph15081679]
Rebuilding the gut microbiota ecosystem
Gagliardi, AntonellaData Curation
;Totino, ValentinaData Curation
;Cacciotti, FatimaData Curation
;Iebba, ValerioData Curation
;Neroni, BrunaData Curation
;Bonfiglio, GiuliaData Curation
;Trancassini, MariaWriting – Original Draft Preparation
;Passariello, ClaudioWriting – Original Draft Preparation
;Pantanella, FabrizioWriting – Original Draft Preparation
;Schippa, Serena
Writing – Original Draft Preparation
2018
Abstract
A microbial ecosystem in which bacteria no longer live in a mutualistic association is called dysbiotic. Gut microbiota dysbiosis is a condition related with the pathogenesis of intestinal illnesses (irritable bowel syndrome, celiac disease, and inflammatory bowel disease) and extra-intestinal illnesses (obesity, metabolic disorder, cardiovascular syndrome, allergy, and asthma). Dysbiosis status has been related to various important pathologies, and many therapeutic strategies aimed at restoring the balance of the intestinal ecosystem have been implemented. These strategies include the administration of probiotics, prebiotics, and synbiotics; phage therapy; fecal transplantation; bacterial consortium transplantation; and a still poorly investigated approach based on predatory bacteria. This review discusses the various aspects of these strategies to counteract intestinal dysbiosis.File | Dimensione | Formato | |
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Gagliardi_Rebuilding_2018.pdf
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