HIGH AMINOACID AND ENERGY INTAKE INFLUENCE THE LEVELS OF ZINC IN THE PRETERM NEONATE Objectives and study. Zinc is a key element for protein synthesis and growth in fetus and preterm newborn. Recent guidelines for preterm nutrition recommend an earlier and higher intake of amino acids (AA) and energy to avoid postnatal catabolism and approximate normal fetal growth. Adequate AA and energy supply, inducing anabolic state and promoting protein synthesis, may increase consumption of zinc in the growing newborn. We performed a prospective observational study to assess the effect of nutrients intake on zinc status of preterm neonates, and their relation with postnatal growth. Methods. We enrolled neonates with GA of 24-36 weeks consecutively observed in our Unit during a period of six months. We excluded subjects with major pre- and post-natal complications of preterm birth. Serum levels of zinc were measured at 0-24 h (T0), 7 (T1) and 28 (T2) days of life by atomic absorption spectroscopy. Data regarding demographic and clinical characteristics and nutritional intake were collected during the entire hospitalization period. Results. We enrolled 54 neonates (birth weight 1786 g; gestational age 31 weeks; males 25.5 %). We observed a zinc deficiency in 50% and 87% of neonates, at T1 and T2, respectively. In subjects with zinc deficiency at T2, we observed an increased energy (103 vs 65 Kcal/Kg/day) and protein (3.4 vs 2.2 g/Kg/day) intake compared with neonates with normal serum value of zinc at the same time point. A significant correlation between energy (r=0.451, p=0.031) and protein (r=0.455, p=0.034) intake and serum zinc levels was also demonstrated at T2. In subjects with zinc deficiency, we observed a higher mean daily body weight increase in comparison with subjects with normal levels of zinc at T1. Conclusions. Occurrence of zinc deficiency in preterm neonates was very high. Zinc status of preterm neonates was influenced by early protein and energy intake. Additional zinc supplementation could be considered when a high nutritional intake was provided to a premature baby.

HIGH AMINO ACID AND ENERGY INTAKE INFLUENCE THE LEVELS OF ZINC IN THE PRETERM NEONATE / Terrin, G.; Di Chiara, M.; Pietravalle, A.; Monaco, S.; Cautilli, F.; D’Aquino, E.; De Curtis, M.. - ELETTRONICO. - (2016). (Intervento presentato al convegno ESPGHAN 49th ANNUAL MEETING of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition tenutosi a ATENE).

HIGH AMINO ACID AND ENERGY INTAKE INFLUENCE THE LEVELS OF ZINC IN THE PRETERM NEONATE

Terrin G.
;
Di Chiara M.;Pietravalle A.;Cautilli F.;D’Aquino E.;De Curtis M.
2016

Abstract

HIGH AMINOACID AND ENERGY INTAKE INFLUENCE THE LEVELS OF ZINC IN THE PRETERM NEONATE Objectives and study. Zinc is a key element for protein synthesis and growth in fetus and preterm newborn. Recent guidelines for preterm nutrition recommend an earlier and higher intake of amino acids (AA) and energy to avoid postnatal catabolism and approximate normal fetal growth. Adequate AA and energy supply, inducing anabolic state and promoting protein synthesis, may increase consumption of zinc in the growing newborn. We performed a prospective observational study to assess the effect of nutrients intake on zinc status of preterm neonates, and their relation with postnatal growth. Methods. We enrolled neonates with GA of 24-36 weeks consecutively observed in our Unit during a period of six months. We excluded subjects with major pre- and post-natal complications of preterm birth. Serum levels of zinc were measured at 0-24 h (T0), 7 (T1) and 28 (T2) days of life by atomic absorption spectroscopy. Data regarding demographic and clinical characteristics and nutritional intake were collected during the entire hospitalization period. Results. We enrolled 54 neonates (birth weight 1786 g; gestational age 31 weeks; males 25.5 %). We observed a zinc deficiency in 50% and 87% of neonates, at T1 and T2, respectively. In subjects with zinc deficiency at T2, we observed an increased energy (103 vs 65 Kcal/Kg/day) and protein (3.4 vs 2.2 g/Kg/day) intake compared with neonates with normal serum value of zinc at the same time point. A significant correlation between energy (r=0.451, p=0.031) and protein (r=0.455, p=0.034) intake and serum zinc levels was also demonstrated at T2. In subjects with zinc deficiency, we observed a higher mean daily body weight increase in comparison with subjects with normal levels of zinc at T1. Conclusions. Occurrence of zinc deficiency in preterm neonates was very high. Zinc status of preterm neonates was influenced by early protein and energy intake. Additional zinc supplementation could be considered when a high nutritional intake was provided to a premature baby.
2016
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1121704
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