Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0 months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan-Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20-2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76-4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48-3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.
Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study / Raparelli, Valeria; Pastori, Daniele; Pignataro, Serena Francesca; Vestri, Anna Rita; Pignatelli, Pasquale; Cangemi, Roberto; Proietti, Marco; Davì, Giovanni; Hiatt, William Robert; Lip, Gregory Yoke Hong; Corazza, Gino Roberto; Perticone, Francesco; Violi, Francesco; Basili, Stefania; Alessandri, C; Serviddio, G; Palange, P; Greco, E; Bruno, G; Averna, M; Giammanco, A; Sposito, P; De Cristofaro, R; Carulli, L; De Gennaro, L; Pellegrini, E; Cominacini, L; Mozzini, C; Pasini, Af; Sprovieri, M; Spagnuolo, V; Cerqua, G; Cerasola, G; Mulé, G; Barbagallo, M; Lo Sciuto, S; Monteverde, A; Saitta, A; Lo Gullo, A; Malatino, L; Cilia, C; Terranova, V; Pisano, M; Pinto, A; Di Raimondo, D; Tuttolomondo, A; Conigliaro, R; Signorelli, S; De Palma, D; Galderisi, M; Cudemo, G; Galletti, F; Fazio, V; De Luca, N; Meccariello, A; Caputo, D; De Donato, Mt; Iannuzi, A; Bresciani, A; Giunta, R; Utili, R; Iorio, V; Adinolfi, Le; Sellitto, C; Iuliano, N; Bellis, P; Tirelli, P; Sacerdoti, D; Vanni, D; Ciacciarelli, M; Pacelli, A; Palazzuoli, A; Cacciafesta, M; Gueli, N; Lo Iacono, C; Brusco, S; Verrusio, W; Nobili, L; Tarquinio, N; Pellegrini, F; Vincentelli, Gm; Ravallese, F; Santini, C; Letizia, C; Petramala, L; Zinnamosca, L; Minisola, S; Cilli, M; Colangelo, L; Falaschi, P; Martocchia, A; Pastore, F; Bertazzoni, G; Attalla El Halabieh, Elias; Paradiso, M; Lizzi, Em; Timmi, S; Battisti, P; Cerci, S; Ciavolella, M; Di Veroli, C; Malci, F; De Ciocchis, A; Abate, D; Castellino, P; Zanoli, L; Fidone, F; Mannarino, E; Pasqualini, L; Oliverio, G; Pende, A; Artom, N; Ricchio, R; Fimognari, Fl; Alletto, M; Messina, S; Sesti, G; Arturi, F; Succurro, E; Fiorentino, Tv; Pedace, E; Scarpino, Pe; Carullo, G; Maio, R; Sciacqua, A; Frugiuele, P; Spagnuolo, V; Battaglia, G; Atzori, S; Delitala, G; Angelucci, E; Sestili, S; Traisci, G; De Feudis, L; Di Michele, D; Fava, A; Balsano, C; De Ciantis, P; Desideri, G; Camerota, A; Mezzetti, M; Gresele, P; Vedovati, C; Fierro, T; Puccetti, L; Bertolotti, M; Mussi, C; Boddi, M; Savino, A; Contri, S; Degl'Innocenti, G; Saller, A; Fabris, F; Pesavento, R; Filippi, L; Vedovetto, V; Puato, M; Fabris, F; Treleani, M; De Luca, E; De Zaiacomo, F; Giantin, V; Semplicini, A; Minuz, P; Romano, S; Fantin, F; Manica, A; Stockner, I; Pattis, P; Gutmann, B; Catena, C; Colussi, G; Sechi, La; Annoni, G; Bruni, Aa; Castagna, A; Spinelli, D; Miceli, E; Padula, D; Schinco, G; Spreafico, S; Secchi, B; Vanoli, M; Casella, G; Pulixi, Ea; Sansone, L; Serra, Mg; Longo, S; Antonaci, S; Belfiore, A; Frualdo, M; Palasciano, G; Ricci, L; Ventrella, F; Bianco, C; Santovito, D; Cipollone, F; Nicolai, S; Salvati, F; Rini, Gb; Scozzari, F; Muiesan, Ml; Salvetti, M; Bazza, A; Picardi, A; Vespasiani-Gentilucci, U; De Vincentis, A; Cosio, P; Terzolo, M; Madaffari, B; Parasporo, B; Fenoglio, L; Bracco, C; Melchio, R; Gentili, T; Salvi, A; Nitti, C; Gabrielli, A; Martino, Gp; Capucci, A; Brambatti, M; Sparagna, A; Tirotta, D; Andreozzi, P; Ettorre, E; Viscogliosi, G; Servello, A; Musumeci, M; Delfino, M; Giorgi, A; Glorioso, N; Melis, G; Marras, G; Matta, M; Sacco, A; Stellitano, E; Scordo, A; Russo, F; Caruso, Aa; Porreca, E; Tana, M; Ferri, C; Cheli, P; Portincasa, P; Muscianisi, G; Giordani, S; Stanghellini, V; Sabbà, C; Mancuso, G; Bartone, M; Calipari, D; Arcidiacono, G; Bellanuova, I; Ferraro, M; Marigliano, G; Cozzolino, D; Lampitella, A; Acri, V; Galasso, D; Mazzei, F; Buratti, A; Galasso, S; Porta, M; Brizzi, Mf; Fattorini, A; Sampietro, F; D'Angelo, A; Manfredini, R; Pala, M; Fabbian, F; Moroni, C; Valente, L; Lopreiato, F; Parente, F; Granata, M; Moia, M; Braham, S; Rossi, M; Pesce, M; Gentile, A; Catozzo, V; Baciarello, G; Cosimati, A; Ageno, W; Rancan, E; Guasti, L; Ciccaglioni, A; Negri, S; Polselli, M; Prisco, D; Marcucci, R; Ferro, D; Perri, L; Cangemi, R; Saliola, M; Del Ben, M; Angelico, F; Baratta, F; Migliacci, R; Porciello, G; Corrao, S; Proietti, M; Raparelli, V; Napoleone, L; Talerico, G; Amoroso, D; Romiti, Gf; Ruscio, E; Toriello, F; Sperduti, N; Todisco, T; Di Tanna, G; Sacchetti, Ml; Puddu, Pe; Farcomeni, A; Anzaldi, M; Bazzini, C; Bianchi, Pi; Boari, B; Bracco, C; Buonauro, A; Buttà, C; Buzzetti, E; Calabria, S; Capeci, W; Caradio, F; Carleo, P; Carrabba, Md; Castorani, L; Cecchetto, L; Cicco, S; Cimini, C; Colombo, Bm; De Giorgi, A; De Vuono, S; Del Corso, L; Denegri, A; Di Giosia, P; Durante Mangoni, E; Falsetti, L; Forgione, A; Giorgini, P; Grassi, D; Grembiale, A; Hijazi, D; Iamele, L; Lorusso, G; Marchese, A; Marra, Am; Masala, M; Miceli, G; Montebianco Abenavoli, L; Murgia, G; Naccarato, P; Padula, D; Pattoneri, P; Perego, F; Pesce, P; Piano, S; Pinna, M; Pinto, D; Pretti, V; Pucci, G; Salinaro, F; Salzano, A; Santilli, F; Scarpini, F; Scicali, R; Sirico, D; Suppressa, P; Talia, M; Tassone, Ej; Torres, D; Vazzana, N; Vecchio, Cr; Vidili, G; Vitale, F; Zaccone, V.. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 13:5(2018), pp. 651-660. [10.1007/s11739-018-1835-9]
Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study
Raparelli, ValeriaPrimo
;Pastori, DanieleSecondo
;Vestri, Anna Rita;Pignatelli, Pasquale;Cangemi, Roberto;Proietti, Marco;Violi, Francesco;Basili, Stefania;Alessandri C;Palange P;Giunta R;Ciacciarelli M;Pacelli A;Cacciafesta M;Gueli N;Verrusio W;Santini C;Petramala L;Zinnamosca L;Minisola S;Cilli M;Colangelo L;Falaschi P;Bertazzoni G;ATTALLA EL HALABIEH, Elias;Desideri G;Sansone L;Andreozzi P;Ettorre E;Viscogliosi G;Servello A;Giorgi A;Moroni C;Granata M;Cosimati A;Ciccaglioni A;Negri S;Polselli M;Marcucci R;Ferro D;Perri L;Cangemi R;Saliola M;Del Ben M;Angelico F;Baratta F;Proietti M;Napoleone L;Talerico G;Amoroso D;Romiti GF;Ruscio E;Toriello F;Di Tanna G;Sacchetti ML;Puddu PE;Farcomeni A;
2018
Abstract
Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0 months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan-Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20-2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76-4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48-3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.| File | Dimensione | Formato | |
|---|---|---|---|
|
Raparelli_Major-Adverse-Cardiovascular_2018.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
757.44 kB
Formato
Adobe PDF
|
757.44 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
