BACKGROUND: The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. OBJECTIVES: To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. METHODS: Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. RESULTS: Latent tuberculosis infection was diagnosed in 8·3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4·3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen-ultraviolet A (P < 0·05). Independent factors associated with LTBI were male sex [odds ratio (OR) 1·30, 95% confidence interval (CI) 1·04-1·62; P = 0·02], age over 55 years (OR 2·93, 95% CI 2·18-3·93; P < 0·001) and being entered into a conventional treatment (OR 3·83, 95% CI 3·10-4·74; P < 0·001). Positive history of tuberculosis was seen in 1% of patients (n = 49). CONCLUSIONS: The nationwide prevalence of LTBI in Italian patients with psoriasis candidate to systemic treatment is high, and screening is recommended prior to biological treatment.
Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry / Gisondi, P; Cazzaniga, S; Chimenti, S; Maccarone, M; Picardo, M; Girolomoni, G; Naldi, L; Psocare Study Group., Griseta V; Miracapillo, A; Azzini, M; Mocci, L; Michelini, M; Offidani, A; Bernardini, L; Campanati, A; Ricotti, G; Giacchetti, Alessandro; Norat, M; Gualco, F; Castelli, A; Cuccia, A; Diana, A; Roncarolo, G; Belli, Ma; Baldassarre, Ma; Santoro, G; Vena, Ga; Lo Console, F; Filotico, R; Mastrandrea, V; Brunetti, B; Musumeci, F; Carrabba, E; Dal Mas, P; Annicchiarico, F; Benvegnù, B; Spaziani, G; Cusano, F; Saletta Iannazzone, S; Galluccio, A; Pezza, M; Marchesi, L; Imberti, G; Reseghetti, A; Barbera, Claudia; Reggiani, Matteo; Lanzoni, A; Patrizi, A; Bardazzi, F; Antonucci, A; De Tommaso, S; Balestri, R; Wallnofer, W; Ingannamorte, F; Calzavara-Pinton, P; Iannazzi, S; Zane, C; Capezzera, R; Bassisi, S; Rossi, Mt; Altamura, V; Vigl, W; SCHETTINO NOBILE, Carla; Aste, N; Murgia, S; Mugheddu, C; Scuderi, G; Baglieri, F; Di Dio, C; Cilioni Grilli, E; Mastronardi, C; Agnusdei, Cp; Antrilli, A; Aulisa, L; Raimondo, U; Scotto di Luzio, G; Battarra, Vc; Farro, P; Plaitano, R; Micali, G; Musumeci, Ml; D'Armiento, Massimino; Li Calzi, M; LA GRECA, SEBASTIANO VITTORIO; Pettinato, Cristiana Maria; Sapienza, G; Valenti, G; De Giacomo, Pf; D'Amico, D; Arcangeli, Federica; Brunelli, D; Ghetti, E; Tulli, Augusta; Assi, G; Amerio, P; Laria, G; Prestinari, F; Spadafora, S; Coppola, M; Caresana, G; Pezzarossa, E; Domaneschi, E; Felisi, C; Donato, L; Bertero, M; Musso, L; Pa Lazzini, S; Bruscino, P; Agozzino, Uc; Ottaviani, M; Simoncini, Cristiana; Virgili, A; Osti, F; Fabbri, P; Volpi, Walter; Caproni, M; Lotti, T; Prignano, F; Buggiani, G; Troiano, M; Fenizi, G; Altobella, A; Amoruso, A; Condello, M; Goffredo, A; Righini, Mg; Alessandrini, F; Satolli, F; Zampetti, M; Bertani, E; Fossati, S; Parodi, A; Burlando, M; Fiorucci, C; Nigro, A; Ghigliotti, G; Massone, L; Moise, Gm; Serrai, M; Cannata, G; Campagnoli, Am; Daly, M; Leporati, C; Peila, R; Filosa, Giovanna; Bugatti, L; Nicolini, M; Nazzari, G; Cestari, R; Anastasio, Fabio; Larussa, Fm; Pollice, N; De Francesco, F; Mazzocchetti, G; Peris, K; Fargnoli, Mc; Di Cesare, A; De Angelis, L; Flati, G; Biamonte, As; Quarta, Giovanni; Congedo, M; Carcaterra, A; Strippoli, D; Fideli, D; Marsili, Filippo; Celli, M; Ceccarini, M; Bachini, L; D ORIA, MARIA FEDERICA; Schirripa, V; De Filippi, C; Martini, P; Lapucci, E; Mazzatenta, C; Ghilardi, A; Simonacci, M; Bettacchi, A; Gasco, R; Zanca, A; Battistini, Simone; Dattola, S; Vernaci, R; Postorino, F; Zampieri, Pf; Padovan, MARIA CRISTINA; González Intchaurraga, Ma; Ladurner, J; Guarneri, B; Cannavo', Serena; Manfrè, C; Borgia, F; Puglisi Guerra, A; Sedona, P; Cattaneo, A; Carrera, C; Fracchiolla, C; Mozzanica, N; Prezzemolo, L; Menni, S; Lodi, A; Martino, P; Monti, M; Mancini, L; Sacrini, F; Altomare, Gf; Taglioni, M; Lovati, C; Mercuri, Sr; Schiesari, G; Giannetti, A; Conti, A; Lasagni, C; Greco, M; Ronsini, G; Schianchi, S; Fiorentini, C; Niglietta, S; Miglietta, R; Padalino, C; Crippa, D; Pini, M; Rossi, E; Tosi, D; Armas, M; Ruocco, V; Ayala, F; Balato, N; Gaudiello, F; Cimmino, Gf; Monfrecola, G; Gallo, L; Argenziano, G; Fulgione, E; Berruti, G; Mozzillo, R; Ceparano, S; De Michele, I; Giorgiano, D; Leigheb, G; Deledda, S; Peserico, A; Alaibac, M; Piaserico, S; Schiesari, L; Dan, G; Mattei, I; Oro, E; Aricò, M; Bongiorno, Mr; Angileri, Rosalia; Amato, S; Todaro, F; Milioto, M; Bellastro, R; Di Nuzzo, S; De Panfilis, G; Zanni, M; Borroni, G; Cananzi, R; Brazzelli, V; Lisi, P; Stingeni, L; Hansel, K; Pierfelice, V; Donelli, S; Rastelli, D; Gasperini, M; Barachini, P; Cecchi, R; Bartoli, L; Pavesi, Maria Gabriella; De Paola, S; Corradin, Mt; Ricciuti, F; Piccirillo, Alessandro; Viola, L; Tataranni, M; Mautone, Mg; Lo Scocco, G; Niccoli, Mc; Brunasso Vernetti, Am; Gaddoni, G; DI RESTA, Fabio; Casadio, Mc; Arcidiaco, Mc; Luvarà, Mc; ALBERTINI PETRONI, Guglielmo; DI LERNIA, Valerio; Guareschi, E; Catrani, S; Morri, M; Amerio, P; De Simone, C; D'Agostino, M; Agostino, I; Calvieri, S; Cantoresi, F; Richetta, A; Sorgi, Paola; Carnevale, C; Nicolucci, F; Berardesca, E; Ardigò, M; De Felice, C; Gubinelli, E; Chimenti, S; Talamonti, Marina; Camplone, G; Cruciani, Giulio; Riccardi, F; Barbati, R; Zumiani, G; Pagani, W; Malagoli, Pg; Pellicano, R; Donadio, Diego; Di Vito, C; Cottoni, F; Montesu, Ma; Pirodda, C; Addis, G; Marongiu, P; Farris, A; Cacciapuoti, Anna Maria; Verrini, A; Desirello, G; Gnone, M; Fimiani, M; Pellegrino, M; Castelli, G; Zappalà, L; Sesana, G; Ingordo, V; Vozza, E; Di Giuseppe, D; Fasciocco, D; Nespoli, P; Papini, M; Cicoletti, M; Bernengo, Mg; Ortoncelli, M; Bonvicino, A; Capella, G; Doveil, Gc; Forte, M; Peroni, A; Salomone, B; Savoia, P; Pippione, M; Zichichi, Ludovica; Frazzitta, M; De Luca, G; Zumiani, G; Tasin, L; Simonetto, D; Ros, S; Trevisan, G; Patamia, M; Miertusova, S; Patrone, Pietro; Frattasio, A; Piccirillo, Fabiola; La Spina, S; Di Gaetano, L; Marzocchi, V; Motolese, A; Venturi, Caterina; Sedona, P; Gai, Francesco; Pasquinucci, S; Bellazzi, Rm; Silvestri, Tommaso; Girolomoni, G; Gisondi, P; Veller Fornasa, C; Trevisan, Gp.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 1365-2133. - 172:6(2015), pp. 1613-1620. [10.1111/bjd.13539]
Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry
Maccarone M;GIACCHETTI, ALESSANDRO;Baldassarre MA;Brunetti B;BARBERA, CLAUDIA;REGGIANI, MATTEO;SCHETTINO NOBILE, Carla;Massimino D;LA GRECA, SEBASTIANO VITTORIO;PETTINATO, Cristiana Maria;ARCANGELI, FEDERICA;TULLI, Augusta;Spadafora S;SIMONCINI, Cristiana;Osti F;VOLPI, WALTER;Fiorucci C;FILOSA, Giovanna;ANASTASIO, FABIO;Flati G;QUARTA, GIOVANNI;Carcaterra A;MARSILI, FILIPPO;D ORIA, MARIA FEDERICA;Martini P;Lapucci E;BATTISTINI, Simone;PADOVAN, MARIA CRISTINA;CANNAVO', SERENA;Oro E;ANGILERI, Rosalia;Pavesi, Maria Gabriella;PICCIRILLO, Alessandro;DI RESTA, FABIO;ALBERTINI PETRONI, Guglielmo;DI LERNIA, VALERIO;Calvieri S;Cantoresi F;Richetta A;SORGI, PAOLA;Nicolucci F;TALAMONTI, MARINA;Camplone G;CRUCIANI , GIULIO;DONADIO, DIEGO;CACCIAPUOTI, Anna Maria;ZICHICHI, LUDOVICA;Ros S;PATRONE, Pietro;PICCIRILLO, FABIOLA;VENTURI, Caterina;GAI, Francesco;SILVESTRI, TOMMASO;
2015
Abstract
BACKGROUND: The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. OBJECTIVES: To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. METHODS: Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. RESULTS: Latent tuberculosis infection was diagnosed in 8·3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4·3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen-ultraviolet A (P < 0·05). Independent factors associated with LTBI were male sex [odds ratio (OR) 1·30, 95% confidence interval (CI) 1·04-1·62; P = 0·02], age over 55 years (OR 2·93, 95% CI 2·18-3·93; P < 0·001) and being entered into a conventional treatment (OR 3·83, 95% CI 3·10-4·74; P < 0·001). Positive history of tuberculosis was seen in 1% of patients (n = 49). CONCLUSIONS: The nationwide prevalence of LTBI in Italian patients with psoriasis candidate to systemic treatment is high, and screening is recommended prior to biological treatment.| File | Dimensione | Formato | |
|---|---|---|---|
|
Gisondi_Latent-tuberculosis_2015.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
95.93 kB
Formato
Adobe PDF
|
95.93 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
