Hernatological abnormalities frequently occur in patients infected with HTV-1. Increasing evidence indicates that bone marrow (BM) suppression results from viral infection of accessory cells, with impaired stromal function and alteration of hematopoietic growth factor network. We investigated the effects of antiretroviral therapy on cytokine and chemokine production by BM cells and stromal cells, in a group of HIV-I-infected subjects before and during treatment. Compared with uninfected controls, an altered cytokine and chemokine production by BM cells has been observed before treatment, characterised by decreased IL-2 and elevated TNF-alpha, MIP-1 alpha, MIP-1 beta, and RANTES levels, along with a defective BM clonogenic activity. Antiretroviral therapy determined an amelioration of stem cell activity; a restoration of stromal cell pattern and functions, and an increased IL-2 production at BM level and a decrease of Fas expression on progenitor cells, in parallel with the diminution of TNF-alpha levels. HIV-1 protease inhibitors (PIs) may improve hematopoietic functions owing to their direct effects on the BM progenitor cells. Ritonavir and indinavir increased the colony growth of BM obtained either from HIV-1-infected patients or from normal individuals, in parallel with the normalization of functional and morphologic characteristics of stromal cells. (c) 2005 Elsevier B.V. All rights reserved.
Immunodysregulation of HIV disease at bone marrow level / Antonella, Isgro; Alessandro, Aiuti; Wilma, Leti; Claudia, Gramiccioni; Antonella, Esposito; Mezzaroma, Ivano; Aiuti, Fernando. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - STAMPA. - 4:8(2005), pp. 486-490. (Intervento presentato al convegno Conference on Immunodysregulation Diseases - From Basic Sciences to Clinic tenutosi a Arenzano, ITALY nel DEC 03-04, 2004) [10.1016/j.autrev.2005.04.014].
Immunodysregulation of HIV disease at bone marrow level
MEZZAROMA, Ivano;AIUTI, Fernando
2005
Abstract
Hernatological abnormalities frequently occur in patients infected with HTV-1. Increasing evidence indicates that bone marrow (BM) suppression results from viral infection of accessory cells, with impaired stromal function and alteration of hematopoietic growth factor network. We investigated the effects of antiretroviral therapy on cytokine and chemokine production by BM cells and stromal cells, in a group of HIV-I-infected subjects before and during treatment. Compared with uninfected controls, an altered cytokine and chemokine production by BM cells has been observed before treatment, characterised by decreased IL-2 and elevated TNF-alpha, MIP-1 alpha, MIP-1 beta, and RANTES levels, along with a defective BM clonogenic activity. Antiretroviral therapy determined an amelioration of stem cell activity; a restoration of stromal cell pattern and functions, and an increased IL-2 production at BM level and a decrease of Fas expression on progenitor cells, in parallel with the diminution of TNF-alpha levels. HIV-1 protease inhibitors (PIs) may improve hematopoietic functions owing to their direct effects on the BM progenitor cells. Ritonavir and indinavir increased the colony growth of BM obtained either from HIV-1-infected patients or from normal individuals, in parallel with the normalization of functional and morphologic characteristics of stromal cells. (c) 2005 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
