We here describe the conceptual advance provided by the study by Battistelli and coworkers (PMID: 27452518), that shed light on a molecular mechanism of Polycomb targeting in the biological process known as Epithelial-to-Mesenchymal Transition (EMT). In this paper, different working hypotheses of how EZH2 gets to its genomic targets have been reconciled and a new paradigm of function for a lncRNA is highlighted. The interest may also arise from the clarification of the role of a lncRNA as a new molecular player in EMT regulation. This evidence holds promise for the development of novel therapeutic targets in carcinoma progression.
Targeting of polycombs to DNA in EMT / Battistelli, Cecilia; Tripodi, Marco; Cicchini, Carla. - In: ONCOTARGET. - ISSN 1949-2553. - 8:35(2017), pp. 57936-57937. [10.18632/oncotarget.20211]
Targeting of polycombs to DNA in EMT
Battistelli, Cecilia;Tripodi, Marco;Cicchini, Carla
Ultimo
2017
Abstract
We here describe the conceptual advance provided by the study by Battistelli and coworkers (PMID: 27452518), that shed light on a molecular mechanism of Polycomb targeting in the biological process known as Epithelial-to-Mesenchymal Transition (EMT). In this paper, different working hypotheses of how EZH2 gets to its genomic targets have been reconciled and a new paradigm of function for a lncRNA is highlighted. The interest may also arise from the clarification of the role of a lncRNA as a new molecular player in EMT regulation. This evidence holds promise for the development of novel therapeutic targets in carcinoma progression.| File | Dimensione | Formato | |
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