Azoospermia, defined as the absence of spermatozoa in ejaculate after centrifugation, results from testicular dysfunction (non-obstructive) or obstruction of extratesticular ducts (obstructive). A variety of conditions, both congenital and acquired, can cause testicular failure, but non invasive biomarkers are not known. MicroRNAs (miRNAs) recently emerged as a different class of short endogenous single-stranded RNAs. Since the discovery of free miRNAs in different human body fluids, much interest has been focused on developing them as biomarkers in various conditions. Although miRNAs play an essential role in spermatogenesis, little is known about seminal plasma miRNAs in azoospermic men. The aim of this work is to determine microRNAs expression in normozoospermic and azoospermic men in order to evaluate their role as biomarkers for diagnosis of male azoospermia.

MicroRNAs expression profile in different types of azoospermia

Finocchi F.;Pelloni M.;Carlini T.;Faja F.;Cefaloni A. C.;CARGNELUTTI, FRANCESCO;Paoli D.;Lombardo F.;Lenzi A.;Gandini L.
2016

Abstract

Azoospermia, defined as the absence of spermatozoa in ejaculate after centrifugation, results from testicular dysfunction (non-obstructive) or obstruction of extratesticular ducts (obstructive). A variety of conditions, both congenital and acquired, can cause testicular failure, but non invasive biomarkers are not known. MicroRNAs (miRNAs) recently emerged as a different class of short endogenous single-stranded RNAs. Since the discovery of free miRNAs in different human body fluids, much interest has been focused on developing them as biomarkers in various conditions. Although miRNAs play an essential role in spermatogenesis, little is known about seminal plasma miRNAs in azoospermic men. The aim of this work is to determine microRNAs expression in normozoospermic and azoospermic men in order to evaluate their role as biomarkers for diagnosis of male azoospermia.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1033794
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