The antifungal activity of unripe grape extracts from agro-industrial wastes has been evaluated against several strains of Candida spp. and dermatophytes. All the extracts tested showed antifungal activity. The geometric mean MIC ranged from 53.58 to 214.31 μg/mL for Candida spp. and from 43.54 to 133.02 μg/mL for dermatophytes. The chemical analyses have been carried out using Liquid Chromatograph equipped with a DAD and MS detectors. Flavan-3-ols were the main metabolites within all samples ranged from 3.3 to 6.8 mg/g fresh weight. For Candida spp. highest negative significant correlation has been found between MICs and polymeric flavan-3-ols (r = −0.842; p < 0.001) and for dermatophytes between MICs and caffeoyl derivatives (r = −0.962; p < 0.01). The results indicate that total extracts obtained from unripe grapes, a large source of waste material derived from the wine industry, could be used as a cheap source of value-added products.

Phenolic content and in vitro antifungal activity of unripe grape extracts from agro-industrial wastes / Simonetti, Giovanna; D'Auria, Felicia Diodata; Mulinacci, Nadia; Milella, Rosa Anna; Antonacci, Donato; Innocenti, Marzia; Pasqua, Gabriella. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 33:6(2019), pp. 803-807. [10.1080/14786419.2017.1410811]

Phenolic content and in vitro antifungal activity of unripe grape extracts from agro-industrial wastes

Simonetti, Giovanna
Project Administration
;
D'Auria, Felicia Diodata
Methodology
;
Pasqua, Gabriella
2019

Abstract

The antifungal activity of unripe grape extracts from agro-industrial wastes has been evaluated against several strains of Candida spp. and dermatophytes. All the extracts tested showed antifungal activity. The geometric mean MIC ranged from 53.58 to 214.31 μg/mL for Candida spp. and from 43.54 to 133.02 μg/mL for dermatophytes. The chemical analyses have been carried out using Liquid Chromatograph equipped with a DAD and MS detectors. Flavan-3-ols were the main metabolites within all samples ranged from 3.3 to 6.8 mg/g fresh weight. For Candida spp. highest negative significant correlation has been found between MICs and polymeric flavan-3-ols (r = −0.842; p < 0.001) and for dermatophytes between MICs and caffeoyl derivatives (r = −0.962; p < 0.01). The results indicate that total extracts obtained from unripe grapes, a large source of waste material derived from the wine industry, could be used as a cheap source of value-added products.
2019
Vitis vinifera; antifungal activity; flavan-3-ols; unripe grapes; waste material from cluster thinning
01 Pubblicazione su rivista::01a Articolo in rivista
Phenolic content and in vitro antifungal activity of unripe grape extracts from agro-industrial wastes / Simonetti, Giovanna; D'Auria, Felicia Diodata; Mulinacci, Nadia; Milella, Rosa Anna; Antonacci, Donato; Innocenti, Marzia; Pasqua, Gabriella. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 33:6(2019), pp. 803-807. [10.1080/14786419.2017.1410811]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1027785
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