Erythroplasia of Queyrat (EQ) is a rare disease involving the mucosal and transitional surfaces of the penis. Effective treatment is necessary to minimize progression to squamous cell carcinoma. The standard therapy for EQ, partial or radical penectomy, is invasive; photodynamic therapy (PDT) may be an effective, non-surgical tissue-sparing option. We report the case of a 67-year-old patient with long-standing EQ who was successfully treated with methyl aminolevulinate-PDT (MAL-PDT). A complete clinical response, confirmed by incisional biopsy, was achieved after five sessions of every-other-week treatment. The patient experienced moderate edema, erythema and pain within 5-7 days after the treatment, without urination problems. Our experience and a review of the published literature suggest that MAL-PDT may represent a valuable treatment option for selected cases of histopathologically-confirmed EQ.

Erythroplasia of Queyrat treated with methyl aminolevulinate-photodynamic therapy / Skroza, Nevena; LA Viola, Giorgio; Pampena, Riccardo; Proietti, Ilaria; Bernardini, Nicoletta; Tolino, Ersilia; Annetta, Alessandro; Zuber, Sara; Balduzzi, Veronica; Potenza, Concetta. - In: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. - ISSN 1827-1820. - 155:1(2020), pp. 103-106. [10.23736/S0392-0488.16.05163-4]

Erythroplasia of Queyrat treated with methyl aminolevulinate-photodynamic therapy

Skroza, Nevena;LA Viola, Giorgio;Pampena, Riccardo;Proietti, Ilaria;Bernardini, Nicoletta;Tolino, Ersilia;Zuber, Sara;Balduzzi, Veronica;Potenza, Concetta
2020

Abstract

Erythroplasia of Queyrat (EQ) is a rare disease involving the mucosal and transitional surfaces of the penis. Effective treatment is necessary to minimize progression to squamous cell carcinoma. The standard therapy for EQ, partial or radical penectomy, is invasive; photodynamic therapy (PDT) may be an effective, non-surgical tissue-sparing option. We report the case of a 67-year-old patient with long-standing EQ who was successfully treated with methyl aminolevulinate-PDT (MAL-PDT). A complete clinical response, confirmed by incisional biopsy, was achieved after five sessions of every-other-week treatment. The patient experienced moderate edema, erythema and pain within 5-7 days after the treatment, without urination problems. Our experience and a review of the published literature suggest that MAL-PDT may represent a valuable treatment option for selected cases of histopathologically-confirmed EQ.
2020
erythroplasia; methyl 5-aminolevulinate; photochemotherapy; carcinoma in situ.
01 Pubblicazione su rivista::01i Case report
Erythroplasia of Queyrat treated with methyl aminolevulinate-photodynamic therapy / Skroza, Nevena; LA Viola, Giorgio; Pampena, Riccardo; Proietti, Ilaria; Bernardini, Nicoletta; Tolino, Ersilia; Annetta, Alessandro; Zuber, Sara; Balduzzi, Veronica; Potenza, Concetta. - In: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. - ISSN 1827-1820. - 155:1(2020), pp. 103-106. [10.23736/S0392-0488.16.05163-4]
File allegati a questo prodotto
File Dimensione Formato  
Skroza_Erythroplasia_2020.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 879.28 kB
Formato Adobe PDF
879.28 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1023174
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact