A new analytical approach to the chemical behaviour of mouse cerebella during ageing is described. The microcalorimetric determination of Na+/K+-ATPase activity and the thermogravimetric investigation of the water-matrix interactions were performed on cerebella of mice of 2, 10 and 22 months (young, adult and aged mice). The results are compared with a preceding work regarding the same determinations performed on cerebella of ouabain-treated mice (spongy-state induced in cerebella of mice as those affected by the Jacob-Creutzfeld disease) and also with similar studies on ageing of brain in mice reported in the literature. The results here obtained on cerebella of aged mice show a substantial difference with respect to those reported for analogous samples of mice affected by a spongy-state.
ATPase Na,K-dependent activity and water-matrix interactions in cerebella of aged mice / Antonelli, Marta Letizia; Curini, Roberta; DE ANGELIS CURTIS, Simonetta Carla Benedett; G., Palladini. - In: THERMOCHIMICA ACTA. - ISSN 0040-6031. - STAMPA. - 364:(2000), pp. 155-163. [10.1016/S0040-6031(00)00650-X]
ATPase Na,K-dependent activity and water-matrix interactions in cerebella of aged mice
ANTONELLI, Marta Letizia;CURINI, Roberta;DE ANGELIS CURTIS, Simonetta Carla Benedett;
2000
Abstract
A new analytical approach to the chemical behaviour of mouse cerebella during ageing is described. The microcalorimetric determination of Na+/K+-ATPase activity and the thermogravimetric investigation of the water-matrix interactions were performed on cerebella of mice of 2, 10 and 22 months (young, adult and aged mice). The results are compared with a preceding work regarding the same determinations performed on cerebella of ouabain-treated mice (spongy-state induced in cerebella of mice as those affected by the Jacob-Creutzfeld disease) and also with similar studies on ageing of brain in mice reported in the literature. The results here obtained on cerebella of aged mice show a substantial difference with respect to those reported for analogous samples of mice affected by a spongy-state.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
