Acrocyanosis, digital ischemia and acronecrosis as first manifestations of endometrial adenocarcinoma: case presentation and literature review

The association between digital ischemia and cancer is rarely reported in literature and the exact mechanism of this occurrence has not been completely understood. We report here a case of a 73 yearold woman who presented digital ischemia as first manifestation of endometrial adenocarcinoma. Reporting this rare clinical case and with a brief literature review, we recommend to consider an intensive search for primary and metastatic cancer in all patients who experience a digital ischemia, with the aim to early detect and treat the disease.