BACKGROUND: Right ventricular (RV) failure is a major determinant of symptoms and shortened survival in pulmonary arterial hypertension (PAH). This study assessed the prognostic relevance of increased right heart (RH) dimensions determined by echocardiography and RH reverse remodeling (RHRR) with targeted therapies in idiopathic PAH (IPAH). METHODS: The study prospectively monitored 102 therapy-naïve IPAH patients for the presence of clinical worsening. Baseline evaluation included RH catheterization and echocardiography. RHRR at the 1-year follow-up was defined by a decrease in RV end-diastolic area, right atrial area, and the left ventricular systolic eccentricity index. RESULTS: At the 1-year follow-up, 18 of 102 patients (17.6%) presented with RHRR. A decrease in pulmonary vascular resistance was the only independent determinant of RHRR. The 94 surviving patients were monitored for 995 ± 529 days. RHRR was an independent prognostic factor and significantly improved the power of the prognostic model based on traditional clinical and hemodynamic parameters. The respective event-free survival rates at 1, 3, and 5 years were 94%, 94%, and 94% in patients with RHRR and 75%, 55%, and 24% in those without RHRR (p ¼ 0.0001). Interestingly, RHRR was able to further stratify patients’ risk assessment through the Registry to Evaluate Early And Long-term PAH Disease Management risk score. CONCLUSIONS: RHRR after 1 year of treatment is an independent predictor of prognosis in IPAH. The likelihood of RHRR is proportional to decreased pulmonary vascular resistance.

Prognostic relevance of right heart reverse remodeling in idiopathic pulmonary arterial hypertension / Badagliacca, Roberto; Poscia, Roberto; Pezzuto, Beatrice; Papa, Silvia; Reali, Manuela; Pesce, Francesca; Manzi, Giovanna; Gianfrilli, Daniele; Ciciarello, Francesco; Sciomer, Susanna; Biondi-zoccai, Giuseppe; Torre, Roberto; Fedele, Francesco; Vizza, Carmine Dario. - In: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. - ISSN 1053-2498. - STAMPA. - 37:2(2018), pp. 195-205. [10.1016/j.healun.2017.09.026]

Prognostic relevance of right heart reverse remodeling in idiopathic pulmonary arterial hypertension

Badagliacca, Roberto
;
Poscia, Roberto;Pezzuto, Beatrice;Papa, Silvia;Reali, Manuela;Pesce, Francesca;Manzi, Giovanna;Gianfrilli, Daniele;Ciciarello, Francesco;Sciomer, Susanna;Biondi-zoccai, Giuseppe;Fedele, Francesco;Vizza, Carmine Dario
2018

Abstract

BACKGROUND: Right ventricular (RV) failure is a major determinant of symptoms and shortened survival in pulmonary arterial hypertension (PAH). This study assessed the prognostic relevance of increased right heart (RH) dimensions determined by echocardiography and RH reverse remodeling (RHRR) with targeted therapies in idiopathic PAH (IPAH). METHODS: The study prospectively monitored 102 therapy-naïve IPAH patients for the presence of clinical worsening. Baseline evaluation included RH catheterization and echocardiography. RHRR at the 1-year follow-up was defined by a decrease in RV end-diastolic area, right atrial area, and the left ventricular systolic eccentricity index. RESULTS: At the 1-year follow-up, 18 of 102 patients (17.6%) presented with RHRR. A decrease in pulmonary vascular resistance was the only independent determinant of RHRR. The 94 surviving patients were monitored for 995 ± 529 days. RHRR was an independent prognostic factor and significantly improved the power of the prognostic model based on traditional clinical and hemodynamic parameters. The respective event-free survival rates at 1, 3, and 5 years were 94%, 94%, and 94% in patients with RHRR and 75%, 55%, and 24% in those without RHRR (p ¼ 0.0001). Interestingly, RHRR was able to further stratify patients’ risk assessment through the Registry to Evaluate Early And Long-term PAH Disease Management risk score. CONCLUSIONS: RHRR after 1 year of treatment is an independent predictor of prognosis in IPAH. The likelihood of RHRR is proportional to decreased pulmonary vascular resistance.
2018
Clinical worsening; echocardiography; idiopathic pulmonary arterial hypertension; morbidity-mortality; right heart remodeling
01 Pubblicazione su rivista::01a Articolo in rivista
Prognostic relevance of right heart reverse remodeling in idiopathic pulmonary arterial hypertension / Badagliacca, Roberto; Poscia, Roberto; Pezzuto, Beatrice; Papa, Silvia; Reali, Manuela; Pesce, Francesca; Manzi, Giovanna; Gianfrilli, Daniele; Ciciarello, Francesco; Sciomer, Susanna; Biondi-zoccai, Giuseppe; Torre, Roberto; Fedele, Francesco; Vizza, Carmine Dario. - In: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. - ISSN 1053-2498. - STAMPA. - 37:2(2018), pp. 195-205. [10.1016/j.healun.2017.09.026]
File allegati a questo prodotto
File Dimensione Formato  
Badagliacca_Prognostic_2018.pdf

solo gestori archivio

Note: articolo principale
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.37 MB
Formato Adobe PDF
1.37 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1017589
Citazioni
  • ???jsp.display-item.citation.pmc??? 25
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 55
social impact