Habitual physical activity has beneficial effects on cardiovascular risk reduction by improving vascular function but the underlying mechanism is still unclear. To address this issue, we performed a cross-sectional study comparing 50 physically active (PA) adults with 50 sedentary controls matched for age, sex, and cardiovascular risk factors. PA subjects had significantly higher flow-mediated dilation (FMD) than controls and higher serum levels of nitrite/nitrate, a marker of nitric oxide generation. In addition, PA subjects showed lower levels of urinary isoprostanes, a marker of reactive oxygen species (ROS) production, and lower serum levels of sNox2-dp, a validated assay to measure Nox2 activity, one of the most important enzymes producing ROS in the blood cells. FMD was independently correlated with sNox2-dp, after adjusting for possible confounding factors. Our observation leads to the hypothesis that, in adults, regular exercise preserves artery dilation through Nox2 decreased activity. Antioxid. Redox Signal. 00, 000-000.

Does regular physical exercise preserve artery dilation by lowering Nox2-related oxidative stress? / Cangemi, Roberto; Loffredo, Lorenzo; Battaglia, Simona; Perri, Ludovica; Santulli, Maria; Carnevale, Roberto; Nocella, Cristina; Muscolo, Miryam; Masala, Daniele; Violi, Francesco. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1557-7716. - 28:17(2018), pp. 1576-1581. [10.1089/ars.2017.7296]

Does regular physical exercise preserve artery dilation by lowering Nox2-related oxidative stress?

Cangemi, Roberto
Primo
;
Loffredo, Lorenzo
Secondo
;
Battaglia, Simona;Perri, Ludovica;Santulli, Maria;Carnevale, Roberto;Nocella, Cristina;Violi, Francesco
Ultimo
2018

Abstract

Habitual physical activity has beneficial effects on cardiovascular risk reduction by improving vascular function but the underlying mechanism is still unclear. To address this issue, we performed a cross-sectional study comparing 50 physically active (PA) adults with 50 sedentary controls matched for age, sex, and cardiovascular risk factors. PA subjects had significantly higher flow-mediated dilation (FMD) than controls and higher serum levels of nitrite/nitrate, a marker of nitric oxide generation. In addition, PA subjects showed lower levels of urinary isoprostanes, a marker of reactive oxygen species (ROS) production, and lower serum levels of sNox2-dp, a validated assay to measure Nox2 activity, one of the most important enzymes producing ROS in the blood cells. FMD was independently correlated with sNox2-dp, after adjusting for possible confounding factors. Our observation leads to the hypothesis that, in adults, regular exercise preserves artery dilation through Nox2 decreased activity. Antioxid. Redox Signal. 00, 000-000.
2018
NADPH oxidase; flow-mediated dilation; oxidative stress; physical activity
01 Pubblicazione su rivista::01a Articolo in rivista
Does regular physical exercise preserve artery dilation by lowering Nox2-related oxidative stress? / Cangemi, Roberto; Loffredo, Lorenzo; Battaglia, Simona; Perri, Ludovica; Santulli, Maria; Carnevale, Roberto; Nocella, Cristina; Muscolo, Miryam; Masala, Daniele; Violi, Francesco. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1557-7716. - 28:17(2018), pp. 1576-1581. [10.1089/ars.2017.7296]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1016637
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