Apolipoprotein A-V (ApoA-V) is a recognized regulator of plasma triglycerides (TGs), and previous studies have shown associations between variants in APOA5 (apolipoprotein-A5) gene and high TG levels. Recently, a new association between the Arg282Ser missense mutation (rs778114184 G > T) in APOA5 gene and decreased triglyceride levels has been shown in an adult population from Sardinia. In this study we add further insight into the role of APOA5 by exploring whether this association begins early in life in children, or becomes manifest only in adulthood. We performed the genetic association analysis of APOA5 in a cohort of 925 overweight and obese children and adolescents from Sardinia, Italy, to see if the genetic burden is already at play before modifying risk factors are interacting.
The Arg282Ser missense mutation in APOA5 gene determines a reduction of triglyceride and LDL-cholesterol in children, together with low serum levels of apolipoprotein A-V / Bertoccini, Laura; Sentinelli, Federica; Incani, Michela; Bailetti, Diego; Cimini, Flavia Agata; Barchetta, Ilaria; Cavallo, Maria Gisella; Cossu, Efisio; Lenzi, Andrea; Loche, Sandro; Baroni, Marco Giorgio. - In: LIPIDS IN HEALTH AND DISEASE. - ISSN 1476-511X. - 16:1(2017), p. 179. [10.1186/s12944-017-0569-4]
The Arg282Ser missense mutation in APOA5 gene determines a reduction of triglyceride and LDL-cholesterol in children, together with low serum levels of apolipoprotein A-V
Bertoccini, Laura;Sentinelli, Federica;Incani, Michela;Bailetti, Diego;Cimini, Flavia Agata;Barchetta, Ilaria;Cavallo, Maria Gisella;Lenzi, Andrea;Baroni, Marco Giorgio
2017
Abstract
Apolipoprotein A-V (ApoA-V) is a recognized regulator of plasma triglycerides (TGs), and previous studies have shown associations between variants in APOA5 (apolipoprotein-A5) gene and high TG levels. Recently, a new association between the Arg282Ser missense mutation (rs778114184 G > T) in APOA5 gene and decreased triglyceride levels has been shown in an adult population from Sardinia. In this study we add further insight into the role of APOA5 by exploring whether this association begins early in life in children, or becomes manifest only in adulthood. We performed the genetic association analysis of APOA5 in a cohort of 925 overweight and obese children and adolescents from Sardinia, Italy, to see if the genetic burden is already at play before modifying risk factors are interacting.File | Dimensione | Formato | |
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