Background: Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis. However, it is difficult to obtain direct proof of their involvement in the etiology of this condition. Case presentation: In order to contribute further evidence of the importance of these viruses, and speculate about disease-relevant interactions between these agents and a predisposed genetic background of the host, we describe the temporal association between multiple sclerosis onset and Herpes simplex 1-encephalitis in a female patient. Conclusions: This case illustrates a possible relationship between HSV-1 encephalitis and multiple sclerosis. Bearing in mind that association does not imply causation, some speculations about the etiology and pathophysiology of the two diseases can be made. The hypothesis of a genetic background predisposing to HSV-1 encephalitis and to immune-mediated demyelination is supported by the coincidence of the two conditions in this patient, along with data from animal models and genetic studies.
Coincident onset of multiple sclerosis and herpes simplex virus 1 encephalitis. a case report / Buscarinu, M. C.; Fornasiero, Arianna; Romano, Silvia; Ferraldeschi, Michela; Renie', Roberta; Trasimeni, Guido; Salvetti, Marco; Ristori, Giovanni. - In: MULTIPLE SCLEROSIS AND DEMYELINATING DISORDERS. - ISSN 2056-6115. - 2:1(2017). [10.1186/s40893-017-0023-5]
Coincident onset of multiple sclerosis and herpes simplex virus 1 encephalitis. a case report
Buscarinu, M. C.;FORNASIERO, ARIANNA;ROMANO, SILVIA;FERRALDESCHI, MICHELA;RENIE', ROBERTA;TRASIMENI, Guido;SALVETTI, Marco;RISTORI, GIOVANNI
2017
Abstract
Background: Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis. However, it is difficult to obtain direct proof of their involvement in the etiology of this condition. Case presentation: In order to contribute further evidence of the importance of these viruses, and speculate about disease-relevant interactions between these agents and a predisposed genetic background of the host, we describe the temporal association between multiple sclerosis onset and Herpes simplex 1-encephalitis in a female patient. Conclusions: This case illustrates a possible relationship between HSV-1 encephalitis and multiple sclerosis. Bearing in mind that association does not imply causation, some speculations about the etiology and pathophysiology of the two diseases can be made. The hypothesis of a genetic background predisposing to HSV-1 encephalitis and to immune-mediated demyelination is supported by the coincidence of the two conditions in this patient, along with data from animal models and genetic studies.File | Dimensione | Formato | |
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