OBJECTIVE: In the present review, the different phenotypes, clinimetric and imaging tools able to assess joint involvement in patients affected by Systemic Lupus Erythematosus (SLE) have been described and summarized. Furthermore, the current knowledge about the pathogenic mechanism and the potential biomarkers of this feature is reported. METHODS: A literature search was done in PubMed, accessed via the National Library of Medicine PubMed interface (http://www.ncbi.nlm.nih.gov/pubmed). Firstly, PubMed was searched using the term "systemic lupus erythematosus" OR "lupus" in combination with (AND) "joint" OR "articular".Secondly, the same PubMed research was combined with other terms, such as "pathogenesis" OR "genetic" OR "antibodies" OR "biomarkers" OR "cytokines" OR "imaging" OR "ultrasonography" OR "magnetic resonance" OR "clinimetry". RESULTS: After a stringent selection, we evaluated in the present review 13 papers concerning clinical phenotypes of SLE joint involvement, 14 concerning clinimetric assessment, 20 concerning imaging, and finally, 28 concerning pathogenesis and biomarkers. Further relevant data were obtained from the reference lists of articles returned using these search terms and from authors own experience and knowledge of the literature. CONCLUSION: Despite the prevalence and severity of SLE joint involvement, more awareness and a deeper evaluation of the clinical heterogeneity of this manifestation are mandatory. Moreover, longitudinal studies are needed to assess the progression of this manifestation and to provide standard definitions and examination/recording protocols.

Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment / Ceccarelli, Fulvia; Perricone, Carlo; Cipriano, Enrica; Massaro, Laura; Natalucci, Francesco; Capalbo, Giuseppe; Leccese, Ilaria; Bogdanos, Dimitrios; Spinelli, FRANCESCA ROMANA; Alessandri, Cristiano; Valesini, Guido; Conti, Fabrizio. - In: SEMINARS IN ARTHRITIS AND RHEUMATISM. - ISSN 0049-0172. - STAMPA. - 47:1(2017), pp. 53-64. [10.1016/j.semarthrit.2017.03.022]

Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment

CECCARELLI, FULVIA;PERRICONE, CARLO;CIPRIANO, ENRICA;MASSARO, LAURA;NATALUCCI, FRANCESCO;LECCESE, ILARIA;SPINELLI, FRANCESCA ROMANA;ALESSANDRI, cristiano;VALESINI, Guido;CONTI, FABRIZIO
2017

Abstract

OBJECTIVE: In the present review, the different phenotypes, clinimetric and imaging tools able to assess joint involvement in patients affected by Systemic Lupus Erythematosus (SLE) have been described and summarized. Furthermore, the current knowledge about the pathogenic mechanism and the potential biomarkers of this feature is reported. METHODS: A literature search was done in PubMed, accessed via the National Library of Medicine PubMed interface (http://www.ncbi.nlm.nih.gov/pubmed). Firstly, PubMed was searched using the term "systemic lupus erythematosus" OR "lupus" in combination with (AND) "joint" OR "articular".Secondly, the same PubMed research was combined with other terms, such as "pathogenesis" OR "genetic" OR "antibodies" OR "biomarkers" OR "cytokines" OR "imaging" OR "ultrasonography" OR "magnetic resonance" OR "clinimetry". RESULTS: After a stringent selection, we evaluated in the present review 13 papers concerning clinical phenotypes of SLE joint involvement, 14 concerning clinimetric assessment, 20 concerning imaging, and finally, 28 concerning pathogenesis and biomarkers. Further relevant data were obtained from the reference lists of articles returned using these search terms and from authors own experience and knowledge of the literature. CONCLUSION: Despite the prevalence and severity of SLE joint involvement, more awareness and a deeper evaluation of the clinical heterogeneity of this manifestation are mandatory. Moreover, longitudinal studies are needed to assess the progression of this manifestation and to provide standard definitions and examination/recording protocols.
2017
Biomarkers; Clinimetry; Imaging; Joint involvement; Pathogenesis; Systemic lupus erythematosus; Rheumatology; Anesthesiology and Pain Medicine
01 Pubblicazione su rivista::01a Articolo in rivista
Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment / Ceccarelli, Fulvia; Perricone, Carlo; Cipriano, Enrica; Massaro, Laura; Natalucci, Francesco; Capalbo, Giuseppe; Leccese, Ilaria; Bogdanos, Dimitrios; Spinelli, FRANCESCA ROMANA; Alessandri, Cristiano; Valesini, Guido; Conti, Fabrizio. - In: SEMINARS IN ARTHRITIS AND RHEUMATISM. - ISSN 0049-0172. - STAMPA. - 47:1(2017), pp. 53-64. [10.1016/j.semarthrit.2017.03.022]
File allegati a questo prodotto
File Dimensione Formato  
Ceccarelli_Joint involvement_2017.pdf

solo gestori archivio

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.01 MB
Formato Adobe PDF
1.01 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/997474
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 53
social impact