INTRODUCTION AND AIM: In cirrhotic patients, the characterization of hypovascular nodules, hypointense on hepatobiliary phase gadoxetic acid disodium-enhanced magnetic resonance images (Gd-EOB-DTPA-enhanced MRI), is essential to look for the proper approach strategy. Our objective was to evaluate the imaging features and risk assessment of hypovascular nodules, hypointense on Gd-EOB-DTPA-enhanced MRI, focusing on the diagnostic value of diffusion-weighted imaging (DWI). MATERIAL AND METHODS: This prospective study includes 35 patients with 50 hypovascular hypointense nodules. Signal intensity on T2-weighted images and DWI, vascular pattern on dynamic contrast-enhanced MRI and on hepatobiliary phase, and volume doubling time were analyzed for each nodule as well as patient's clinical features. Univariate and multivariate analyses were made to determine the variables associated with the development of hypervascular pattern. RESULTS: On 24 months follow-up period, 40% of the hypointense nodules (mean size 14 mm ± 6.1) became hypervascular hepatocellular carcinoma (HCC) with 6 and 12 months cumulative risk of 45 and 55%. Nine/12 (75%, mean size 15.50 mm ± 7.2) that appeared hyperintense in DWI at first exam show malignant transformation (p value = 0.007). Univariate and multivariate analyses identified hyperintensity at initial DWI (OR 6.49; 95% CI 1.28-32.80; p value = 0.009) and size ≥10 mm (OR 6.22; 95% CI 1.57-24.63; p value = 0.024) as independent factors with the development of HCC. CONCLUSION: In conclusion, hypovascular lesions ≥10 mm and those hyperintense in DWI were associated with progression to hypervascular HCC. A close follow-up or histological characterization is recommended to improve patients outcome and to develop effective treatment. KEYWORDS: Diffusion-weighted imaging; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver cirrhosis; MR imaging

Non-hypervascular hypointense nodules at gadoxetic acid MRI. hepatocellular carcinoma risk assessment with emphasis on the role of diffusion-weighted imaging / Briani, Chiara; DI PIETROPAOLO, Marco; Marignani, Massimo; Carbonetti, Francesco; Begini, Paola; David, Vincenzo; Iannicelli, Elsa. - In: JOURNAL OF GASTROINTESTINAL CANCER. - ISSN 1941-6628. - STAMPA. - 49:3(2018), pp. 1-9. [10.1007/s12029-017-9952-7]

Non-hypervascular hypointense nodules at gadoxetic acid MRI. hepatocellular carcinoma risk assessment with emphasis on the role of diffusion-weighted imaging

BRIANI, CHIARA
;
DI PIETROPAOLO, MARCO;CARBONETTI, FRANCESCO;BEGINI, PAOLA;DAVID, vincenzo;IANNICELLI, Elsa
2018

Abstract

INTRODUCTION AND AIM: In cirrhotic patients, the characterization of hypovascular nodules, hypointense on hepatobiliary phase gadoxetic acid disodium-enhanced magnetic resonance images (Gd-EOB-DTPA-enhanced MRI), is essential to look for the proper approach strategy. Our objective was to evaluate the imaging features and risk assessment of hypovascular nodules, hypointense on Gd-EOB-DTPA-enhanced MRI, focusing on the diagnostic value of diffusion-weighted imaging (DWI). MATERIAL AND METHODS: This prospective study includes 35 patients with 50 hypovascular hypointense nodules. Signal intensity on T2-weighted images and DWI, vascular pattern on dynamic contrast-enhanced MRI and on hepatobiliary phase, and volume doubling time were analyzed for each nodule as well as patient's clinical features. Univariate and multivariate analyses were made to determine the variables associated with the development of hypervascular pattern. RESULTS: On 24 months follow-up period, 40% of the hypointense nodules (mean size 14 mm ± 6.1) became hypervascular hepatocellular carcinoma (HCC) with 6 and 12 months cumulative risk of 45 and 55%. Nine/12 (75%, mean size 15.50 mm ± 7.2) that appeared hyperintense in DWI at first exam show malignant transformation (p value = 0.007). Univariate and multivariate analyses identified hyperintensity at initial DWI (OR 6.49; 95% CI 1.28-32.80; p value = 0.009) and size ≥10 mm (OR 6.22; 95% CI 1.57-24.63; p value = 0.024) as independent factors with the development of HCC. CONCLUSION: In conclusion, hypovascular lesions ≥10 mm and those hyperintense in DWI were associated with progression to hypervascular HCC. A close follow-up or histological characterization is recommended to improve patients outcome and to develop effective treatment. KEYWORDS: Diffusion-weighted imaging; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver cirrhosis; MR imaging
diffusion-weighted imaging; hepatocarcinogenesis; hepatocellular carcinoma; liver cirrhosis; MR imaging
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Non-hypervascular hypointense nodules at gadoxetic acid MRI. hepatocellular carcinoma risk assessment with emphasis on the role of diffusion-weighted imaging / Briani, Chiara; DI PIETROPAOLO, Marco; Marignani, Massimo; Carbonetti, Francesco; Begini, Paola; David, Vincenzo; Iannicelli, Elsa. - In: JOURNAL OF GASTROINTESTINAL CANCER. - ISSN 1941-6628. - STAMPA. - 49:3(2018), pp. 1-9. [10.1007/s12029-017-9952-7]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/986986
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