BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters. METHODS: 91 SSc patients were enrolled in this study. Serum VEGF and endostatin levels were determined. All patients underwent a renal Doppler ultrasound RESULTS: A significant positive correlation was observed between endostatin and renal Doppler parameters (p<0.0001). A negative correlation was observed between serum levels of endostatin and eGFR (p<0.01). In SSc patients with high resistive index, serum levels of endostatin were significantly (p<0.01) higher than in SSc patients with normal resistive index. The serum levels of endostatin significantly increased with progression of nailfold videocapillaroscopy damage (p<0.01) and were significantly (p<0.05) higher in SSc patients with digital ulcers than in SSc patients without digital ulcers. CONCLUSION: This is the first study that assess in SSc patients intrarenal hemodynamic parameters and endostatin. In SSc patients, endostatin represents a marker of renal scleroderma-associated vasculopathy.

Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy / Gigante, Antonietta; Navarini, Luca; Margiotta, Domenico; Amoroso, Antonio; Barbano, Biagio; Cianci, Rosario; Afeltra, Antonella M. Vittoria; Rosato, Edoardo. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - STAMPA. - 114:(2017), pp. 41-45. [10.1016/j.mvr.2017.06.003]

Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy

GIGANTE, ANTONIETTA;AMOROSO, Antonio;BARBANO, BIAGIO;CIANCI, ROSARIO;ROSATO, Edoardo
2017

Abstract

BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters. METHODS: 91 SSc patients were enrolled in this study. Serum VEGF and endostatin levels were determined. All patients underwent a renal Doppler ultrasound RESULTS: A significant positive correlation was observed between endostatin and renal Doppler parameters (p<0.0001). A negative correlation was observed between serum levels of endostatin and eGFR (p<0.01). In SSc patients with high resistive index, serum levels of endostatin were significantly (p<0.01) higher than in SSc patients with normal resistive index. The serum levels of endostatin significantly increased with progression of nailfold videocapillaroscopy damage (p<0.01) and were significantly (p<0.05) higher in SSc patients with digital ulcers than in SSc patients without digital ulcers. CONCLUSION: This is the first study that assess in SSc patients intrarenal hemodynamic parameters and endostatin. In SSc patients, endostatin represents a marker of renal scleroderma-associated vasculopathy.
2017
Angiogenesis; Endostatin; Renal resistive index; Systemic sclerosis; VEGF; Biochemistry; Cardiology and Cardiovascular Medicine; Cell Biology
01 Pubblicazione su rivista::01a Articolo in rivista
Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy / Gigante, Antonietta; Navarini, Luca; Margiotta, Domenico; Amoroso, Antonio; Barbano, Biagio; Cianci, Rosario; Afeltra, Antonella M. Vittoria; Rosato, Edoardo. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - STAMPA. - 114:(2017), pp. 41-45. [10.1016/j.mvr.2017.06.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/986637
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